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Appearance and proliferation

Fibrosis is a dynamic progression of dysregulated wound healing that results from chronic inflammation. It is a common pathology regardless of the tissue involved, and therefore, the mechanisms that progress to fibrosis can be widely applied. The recruitment, activation, and proliferation of inflammatory cells and their cooperation with resident cells appears to rely on the action of chemokines and the differential expression of the chemokine receptors by these cells. Thus, chemokine receptors make particularly attractive therapeutic targets. [Pg.310]

Although the influence of lycopene and proliferation of carcinoma cells appears not limited to its ability to modulate Cx43 expression, lycopene as well as its oxidation products have been reported to enhance GJC in cultured cells (Livny et al., 2002 Stahl et al., 2000). Recent data indicate that lycopene may indeed increase connexin-43 expression in human prostate (Kucuk et al., 2001). [Pg.478]

Stars are not living bodies, bnt objects that change strnctnre and appearance. They evolve and proliferate, and that is why they are said to be born, to live and to die. [Pg.94]

The data concerning the effect of fluoride-containing apatites on cell adhesion, proliferation and expression seem rather disparate, probably because of the variation of other surface characteristics and the use of different cell strains. No real negative effect of fluoride-containing substrates has been reported so far and the osteoblast cells seem to behave similarly [184,185] or better [183,186,187] on fluoridated apatites than on HA surfaces. Some reports mention weaker attachment and proliferation, compensated for by improved collagen matrix production [188]. The shape of cells appeared different on fluoridated apatites than on HA. Other authors have found an improvement in cell attachment [183] which has been attributed to the change in surface charge of FA compared to HA. [Pg.321]

The most superficial layer of skin is the stratum comeum (SC), which consists of terminally differentiated keratinocytes (comeocytes) that originate from actively proliferating keratinocytes in lower epidermis (basale, spinosum, and granulosum cells), and contain a lamellar lipid layer secreted from lamellar bodies (Fig. 7a). Flydration of the SC is an important determinant of skin appearance and physical properties, and depends on a number of factors including the external humidity, and its structure, lipid/protein composition, barrier properties, and concentration of water-retaining osmolytes (natural moisturizing factors, NMFs) including free amino acids, ions, and other small solutes. [Pg.46]

AT2 receptors are present at high density in all tissues during fetal development, but they are much less abundant in the adult where they are expressed at high concentration only in the adrenal medulla, reproductive tissues, vascular endothelium, and parts of the brain. AT2 receptors are up-regulated in pathologic conditions including heart failure and myocardial infarction. The functions of the AT2 receptor appear to include fetal tissue development, inhibition of growth and proliferation, cell differentiation, apoptosis, and vasodilation. [Pg.377]

Theratope was given to patients with breast or ovarian cancer who received peripheral blood stem cell rescue after chemotherapy. Toxicity was mostly local. In vitro, NK activity which was low before immunization returned to normal values, toxicity against cells bearing sTn antigen appeared, and lymphocytes responded to sTn, by proliferation and IFN-y production. Antibodies against sTn were detected in 16 patients, while the anti-MUC-1 antibody titer decreased [210]. The remissions were longer in treated patients and there was a tendency to a decreased risk of relapse [211],... [Pg.544]

Estradiol may improve vascular healing, reduce SMC migration and proliferation, and promote local angiogenesis. Indeed, several animal and human studies have demonstrated the protective effect of estrogen on coronary circulation (30-32). Estrogen not only appears to have a beneficial effect on lipids, but also stimulates NO production by ECs, as well as inhibits expression of the proto-oncogene, c-myc, the activity of which is implicated in the development of intimal hyperplasia (3 1,32). [Pg.349]


See other pages where Appearance and proliferation is mentioned: [Pg.294]    [Pg.394]    [Pg.212]    [Pg.163]    [Pg.252]    [Pg.49]    [Pg.294]    [Pg.394]    [Pg.212]    [Pg.163]    [Pg.252]    [Pg.49]    [Pg.150]    [Pg.308]    [Pg.56]    [Pg.254]    [Pg.1334]    [Pg.1373]    [Pg.310]    [Pg.183]    [Pg.158]    [Pg.454]    [Pg.178]    [Pg.215]    [Pg.934]    [Pg.513]    [Pg.795]    [Pg.135]    [Pg.381]    [Pg.67]    [Pg.120]    [Pg.97]    [Pg.266]    [Pg.106]    [Pg.530]    [Pg.11]    [Pg.273]    [Pg.935]    [Pg.150]    [Pg.415]    [Pg.32]    [Pg.126]    [Pg.201]    [Pg.51]    [Pg.373]    [Pg.256]    [Pg.296]   
See also in sourсe #XX -- [ Pg.394 ]




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