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Solid-phase synthesi

Then N-Boc-O-benzylserine is coupled to the free amino group with DCC. This concludes one cycle (N° -deprotection, neutralization, coupling) in solid-phase synthesis. All three steps can be driven to very high total yields (< 99.5%) since excesses of Boc-amino acids and DCC (about fourfold) in CHjClj can be used and since side-reactions which lead to soluble products do not lower the yield of condensation product. One side-reaction in DCC-promoted condensations leads to N-acylated ureas. These products will remain in solution and not reaa with the polymer-bound amine. At the end of the reaction time, the polymer is filtered off and washed. The times consumed for 99% completion of condensation vary from 5 min for small amino acids to several hours for a bulky amino acid, e.g. Boc-Ile, with other bulky amino acids on a resin. A new cycle can begin without any workup problems (R.B. Merrifield, 1969 B.W. Erickson, 1976 M. Bodanszky, 1976). [Pg.232]

The major disadvantage of solid-phase peptide synthesis is the fact that ail the by-products attached to the resin can only be removed at the final stages of synthesis. Another problem is the relatively low local concentration of peptide which can be obtained on the polymer, and this limits the turnover of all other educts. Preparation of large quantities (> 1 g) is therefore difficult. Thirdly, the racemization-safe methods for acid activation, e.g. with azides, are too mild (= slow) for solid-phase synthesis. For these reasons the convenient Menifield procedures are quite generally used for syntheses of small peptides, whereas for larger polypeptides many research groups adhere to classic solution methods and purification after each condensation step (F.M. Finn, 1976). [Pg.237]

We shall describe here one step in the total synthesis of a protected heptatetracontapep-tide ( = 47 amino acids) by K. Hofmann (H.T. Storey, 1972), and compare the techniques and the results with those of solid-phase synthesis. [Pg.237]

Sections 27 15 through 27 17 describe the chemistry associated with the protection and deprotection of ammo and carboxyl functions along with methods for peptide bond formation The focus m those sections is on solution phase peptide synthesis Section 27 18 shows how these methods are adapted to solid phase synthesis... [Pg.1137]

Memfield s concept of a solid phase method for peptide synthesis and his devel opment of methods for carrying it out set the stage for an entirely new way to do chem ical reactions Solid phase synthesis has been extended to include numerous other classes of compounds and has helped spawn a whole new field called combinatorial chemistry Combinatorial synthesis allows a chemist using solid phase techniques to prepare hun dreds of related compounds (called libraries) at a time It is one of the most active areas of organic synthesis especially m the pharmaceutical industry... [Pg.1142]

E. C. Blossey and D. C. Neckers, Eds., Solid Phase Synthesis, Halsted, New York, 1975 P. Hodge and D. C. Sherrington, Eds., Polymer-Supported Reactions in Organic Synthesis, Wiley-Interscience, New York, 1980. A comprehensive review of polymeric protective groups by J. M. J. Frechet is included in this book. [Pg.8]

The major impetus for the development of solid phase synthesis centers around applications in combinatorial chemistry. The notion that new drug leads and catalysts can be discovered in a high tiuoughput fashion has been demonstrated many times over as is evidenced from the number of publications that have arisen (see references at the end of this chapter). A number of )proaches to combinatorial chemistry exist. These include the split-mix method, serial techniques and parallel methods to generate libraries of compounds. The advances in combinatorial chemistry are also accompani by sophisticated methods in deconvolution and identification of compounds from libraries. In a number of cases, innovative hardware and software has been developed tor these purposes. [Pg.75]

A SAMPLE OF REVIEWS ON SOLID PHASE SYNTHESIS General... [Pg.78]

K. Gordon and S. Balasubramanian, Solid phase synthesis - designer linkers for combinatorial chemistry A review J Chem Technol Biotechnol 74 835-851 7999. [Pg.78]

J.W. Labadie, Polymeric Supports for Solid Phase Synthesis, Curr Opin Chem Biol 2 346-352 1998. [Pg.78]

Rapid purification Stir over CaH2 (5% w/v) overnight, filter, then distil at 20mmHg. Store the distd DMF over 3A or 4A molecular sieves. For solid phase synthesis, the DMF used must be of high quality and free from amines. [Pg.216]

Oxytocin [50-56-6] M 1007.2, m dec on heating, [a] -26.2"(c 0.53, N AcOH). A cyclic nonapeptide which was purified by countercurrent distribution between solvent and buffer. It is soluble in H2O, rt-BuOH and isoBuOH. [Bodanszky and du Vigneaud J Am Chem Soc 81 2504 1959 Cash et al. J Med Pharm Chem 5 413 1962 Sakakibara et al. Bull Chem Soc Jpn 38 120 1965 solid phase synthesis Bayer and... [Pg.554]

One widely used method involving protected compounds is solid-phase synthesis (polymer-supponed reagents). This method has the advantage of requiring only a simple workup by filtration such as in automated syntheses, especially of polypeptides, oligonucleotides, and oligosaccharides. [Pg.4]

Other PK variations include microwave conditions, solid-phase synthesis, and the fixation of atmospheric nitrogen as the nitrogen source (27—>28). Hexamethyldisilazane (HMDS) is also an excellent ammonia equivalent in the PK synthesis. For example, 2,5-hexanedione and HMDS on alumina gives 2,5-dimethylpyrrole in 81% yield at room temperature. Ammonium formate can be used as a nitrogen source in the PK synthesis of pyrroles from l,4-diaryl-2-butene-l,4-diones under Pd-catalyzed transfer hydrogenation conditions. [Pg.82]

The adaptation of the Bischler-Napieralski reaction to solid-phase synthesis has been described independently by two different groups. Meutermans reported the transformation of Merrifield resin-bound phenylalanine derivatives 32 to dihydroisoquinolines 33 in the presence of POCI3. The products 34 were liberated from the support using mixtures of HF/p-cresol. In contrast, Kunzer conducted solid-phase Bischler-Napieralski reactions on a 2-hydroxyethyl polystyrene support using the aromatic ring of the substrate 35 as a point of attachment to the resin. The cyclized products 36 were cleaved from the support by reaction with i-butylamine or n-pentylamine to afford 37. [Pg.380]

The von Richter cinnoline process was further extended to solid-phase synthesis. The route began from benzylaminomethyl polystyrene and the required diverse o-haloaryl resins represented by 21 were prepared from substituted o-haloanilines. A Pd-mediated cross-coupling reaction with 21 and the alkynes provided the alkynylaryl derivatives represented by alkyne 22. The von Richter cyclization reaction with hydrobromic or hydrochloric acid in acetone/HaO and cleavage from the resin occurred in the same step to furnish the cinnoline derivatives 23 in 47-95% yield and 60-90% purity (no yield reported for each entry). [Pg.542]

Solid-phase synthesis and transformations of heterocycles 97T5643, 98JCS(P1)3293, 98T15385. [Pg.203]

Solid-phase synthesis of heterocycles 98MI37, 980PP489, 98YGK2. [Pg.213]

More recently, Tietze and Steinmetz (96SL667) used the patented polystyrene-resin methodology for for the solid-phase synthesis of a large number of diverse )3-keto esters 40a-h. These were reacted with phenylhydrazine in THF at room temperature to give hydrazones 41a-h that were then cychzed into 2-phenyl 5-substituted pyrazol-3-ones 42a-h by heating in toluene at 1(X)°C (Scheme 12). [Pg.83]

Substituted 4-aryl-1 -oxo-1,2-dihydropyrazino[l, 2-i]isoquinolinium salts 402 were obtained when 3-substituted isoquinolines 401 were cleaved from a polymer by treatment 25% TFA (00MIP5). c/i-3,lla-H-3-Phenyl-1,2,3,4,11,11 fl-hexahydropyrazino[l, 2-i]isoquinoline-1,4-dione (404) formed when isoquinoline derivative 403 was cleaved from a resin with 25% TFA during an automated solid-phase synthesis (98BMCL2369). [Pg.317]

Preparation of Memfield resin-bound nitro acetates, which is a suitable bndding block for the development of combinatorial solid phase synthesis, is repotted. The anion of ethyl nitro acetate is generated in DMF by an electrochemical method using Pt cathode, magnesium rod anode, and tetrabutylairunonium bromide as an electrolyte. Alkylaton of this anion with alkyl hahdes gives mono-alkylated products in 80% yield." ... [Pg.127]

The classic Reissert indole synthesis, involving the reducdve cyclization of o-ni-trophenylpymvic acid, has been used for synthesis of 2-ethoxycarbonyl-4-alkoxymethylindo-les The modified Reissert reacdon, involving the reducdve cyclizadon of an o-rdtrophenyl acetoaldehyde, has been adapted to solid-phase synthesis... [Pg.344]

On-Bead Solid-Phase Synthesis of Chiral Dipeptides... [Pg.71]


See other pages where Solid-phase synthesi is mentioned: [Pg.366]    [Pg.232]    [Pg.381]    [Pg.72]    [Pg.72]    [Pg.72]    [Pg.620]    [Pg.621]    [Pg.149]    [Pg.150]    [Pg.5]    [Pg.15]    [Pg.15]    [Pg.370]    [Pg.83]    [Pg.84]    [Pg.71]    [Pg.71]    [Pg.95]    [Pg.95]    [Pg.107]    [Pg.63]   
See also in sourсe #XX -- [ Pg.136 , Pg.137 , Pg.138 , Pg.139 , Pg.140 , Pg.141 , Pg.142 , Pg.143 , Pg.144 , Pg.145 , Pg.146 , Pg.147 ]




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A New Technology Solid Phase Peptide Synthesis

A Typical Protocol for Solid-Phase Synthesis

A solid phase synthesis

Alkaloids solid-phase organic synthesis

Amines solid phase synthesis

Amino acids solid phase peptide synthesis

Amino solid-phase synthesis

Amphiphilic Gels for Solid Phase Synthesis

Analytical methods used in solid-phase synthesis

Analytical tools, solid-phase synthesis

Anchors, solid-phase synthesis

Application in Solid-phase Synthesis

Applications solid-phase organic synthesis

Automated Peptide Synthesis The Merrifield Solid-Phase ethod

Automated Solid-Phase Oligosaccharide Synthesis Strategy

Automated oligosaccharide synthesis solid-phase approaches

Automated solid-phase peptide synthesi

Automated solid-phase peptide synthesis

Benzotriazoles solid-phase synthesis

Benzoyl groups, solid-phase synthesis

Biaryls solid-phase synthesis

Biopolymers solid phase synthesis

COLORIMETRIC TEST FOR SOLID-PHASE ORGANIC SYNTHESIS

Carbohydrate libraries, solid-phase synthesis

Carbohydrate library Oligosaccharide solid-phase synthesis

Carbohydrate synthesis acceptor-bound solid-phase

Carbohydrate synthesis solid-phase linkers

Carbohydrates solid phase synthesis

Carbopalladation reactions in solid-phase syntheses

Carboxylic acids solid phase peptide synthesis

Ceramic powder synthesis solid-phase reactants

Chemistry and Solid-Phase Organic Synthesis

Cleavage solid-phase peptide synthesis

Combinatorial Synthesis on Solid Phases

Combinatorial and Solid-Phase Syntheses

Combinatorial chemistry solid-phase library synthesis

Combinatorial chemistry solid-phase parallel synthesis

Combinatorial libraries Solid phase organic synthesis

Combinatorial peptide library solid-phase synthesis

Combinatorial synthesis solid-phase

Controlled-pore glass, solid phase oligosaccharide synthesis

Coupling Reagents and Methods for Solid-Phase Synthesis

Cryochemical syntheses solid-phase

Cyanines solid-phase synthesis

Cyclative cleavage solid-phase synthesis

Dendrimers, solid phase synthesi

Deprotection solid phase peptide synthesis

Deprotection solid phase synthesis

Dipolar solid-phase synthesis

Diversity Linker Units in Solid-Phase Organic Synthesis

Diversity-Oriented Synthesis on Solid Phase

Epothilone solid-phase total synthesis

Esters solid phase peptide synthesis

Esters solid phase synthesis

Examples of Solid-Phase Discrete Library Synthesis

Features and Requirements for Solid-Phase Synthesis

Fmoc Solid-Phase Peptide Synthesis

Fragment condensation, solid-phase protein synthesis

Glycopeptide Synthesis in Solution and on the Solid Phase

Glycopeptide Synthesis on the Solid Phase

Glycopeptides enzymatic solid-phase synthesis

Glycopeptides synthesis on the solid phase

Glycoside synthesis solid phase

Glycosyl trichloroacetimidates automated solid-phase synthesis

Glycosylations solid-phase synthesis

High-Loading Dendronized Supports for Solid-Phase Synthesis

High-performance liquid chromatography solid-phase peptide synthesis

Hydroxamic acids solid-phase synthesis

Indoles solid-phase organic synthesis

Indolines solid-phase synthesis

Insulin, solid phase synthesis

Isonitrile synthesis, solid-phase

Kinases solid-phase synthesis

LINKER STRATEGIES IN MODERN SOLID-PHASE ORGANIC SYNTHESIS

Lactams solid-phase organic synthesis

Large-scale synthesis solid phase

Library solid-phase domino syntheses

Linear solid-phase synthesis

Linker units solid-phase organic synthesis

Linkers in Solid-Phase Synthesis

Linkers, solid-phase synthesis

Lipase-catalyzed solid-phase synthesis

Lipid solid phase synthesis

Manual Solid-Phase Synthesis

Mass spectrometry solid phase synthesis

Mass spectrometry solid-phase peptide synthesis

Merrifield solid phase synthesis method

Merrifield solid phase synthesis, synthetic

Merrifield solid phase synthesis, synthetic methods

Merrifield solid-phase peptide synthesis

Merrifield solid-phase synthesis

Merrifield solid-phase synthesis Fmoc protecting group

Merrifield solid-phase synthesis Wang resin

Merrifield solid-phase synthesis steps

Metathesis Reactions in Solid-phase Organic Synthesis

Microwave chemistry and solid-phase organic synthesis

Microwave-assisted solid-phase peptide synthesis

Microwave-assisted solid-phase synthesis

Microwave-enhanced Solid-phase Peptide Synthesis

NITRIDES solid phase synthesis

Native solid-phase synthesis

Natural products solid phase syntheses

Natural solid-phase synthesis

New Linkers and Protection Groups for Solid-Phase Synthesis of Oligosaccharides

New Trends in Solid-Phase Discrete Library Synthesis

Noncovalent protection, solid-phase peptide synthesis

Nucleic acids synthesis, solid phase

Nucleic solid phase synthesis

Oligomerization solid-phase synthesis

Oligonucleotide synthesis, solid phase

Oligonucleotides, solid phase synthesis

Oligonucleotides, solid phase synthesis protecting groups

Oligosaccharide solid-phase synthesis applications

Oligosaccharide solid-phase synthesis branching

Oligosaccharide solid-phase synthesis cleavage conditions

Oligosaccharide solid-phase synthesis coupling

Oligosaccharide solid-phase synthesis deprotection

Oligosaccharide solid-phase synthesis linkers

Oligosaccharide solid-phase synthesis products

Oligosaccharide synthesis acceptor-bound solid-phase method

Oligosaccharide synthesis automated solid-phase

Oligosaccharides solid-phase organic synthesis

Oligosaccharides solid-phase synthesis

Oligosaccharides solid-phase synthesis, combinatorial approach

Oligothiophenes solid-phase synthesis

Optimization in Solid-Phase Organic Syntheses

Orthogonal solid-phase oligosaccharide synthesis

Oximes solid-phase synthesis

PRACTICAL ASPECTS OF COMBINATORIAL SOLID-PHASE SYNTHESIS

Parallel synthesis solid phase

Penicillin solid phase synthesis

Peptide aldehydes by solid phase synthesis

Peptide synthesis solid phase, disadvantage

Peptide synthesis solid-phase technique

Peptide synthesis, polymerization solid phase

Peptides solid-phase peptide synthesis

Peptides: synthesis solid-phase methods

Photolysis, linker, solid-phase synthesis

Polyethylene glycol , solid-phase synthesis

Polymer-Supported and Solid-Phase Oligosaccharide Synthesis

Polymer-supported chemical Solid-phase synthesis

Polypeptide synthesis solid phase

Polystyrene Resins and Solvation in Solid-Phase Synthesis

Practical Aspects of Solid-Phase Synthesis

Practice of Solid Phase Synthesis and Its Application

Protecting Group Combinations for Solid-Phase Synthesis

Protecting Groups and Solid-Phase Synthesis

Protecting groups solid phase peptide synthesis

Protecting groups, deprotection solid phase peptide synthesis

Protein synthesis from solid phase peptide synthesi

Proteins solid-phase synthesis

Purines, solid-phase synthesis

Purity and Yield Determination in Solid-Phase Synthesis

Quinazoline-2,4-diones, solid-phase synthesi

Quinazolines solid-phase synthesis

RECENT ADVANCES IN SOLID-PHASE SYNTHESIS OF NATURAL PRODUCTS

Reaction Monitoring in Solid-Phase Synthesis

Reductive cyclization solid-phase synthesis

Resins, solid-phase oxime synthesis

Reviews on Linkers in Solid-Phase Synthesis

SOLID-PHASE ORGANIC SYNTHESIS ON RADIATION-GRAFTED POLYMER SURFACES APPLICATION OF SYNPHASE CROWNS TO MULTIPLE PARALLEL SYNTHESES

SOLID-PHASE SYNTHESIS OF HETEROCYCLES FROM PEPTIDES AND AMINO ACIDS

SOLID-PHASE SYNTHESIS OF SEQUENCE-SPECIFIC PHENYLACETYLENE OLIGOMERS

SULFONES IN SOLID-PHASE HETEROCYCLE SYNTHESIS

Saccharide solid-phase synthesis

Scavenger compounds, solid-phase organic synthesis

Screening solid phase synthesis

Sequential solid phase peptide synthesis

Small-molecule compounds solid-phase organic synthesis

Solid Phase Deoxyribonucleotide Synthesis

Solid Phase Organic Synthesis Without Using Any Solvent

Solid Phase Synthesis and Biotechnological Approaches

Solid Phase Synthesis database

Solid Phase Synthesis of Heterocycles

Solid Phase Synthesis of aPNA

Solid phase multistep syntheses

Solid phase oligosaccharide synthesis SPOS)

Solid phase organic synthesis peptide arrays

Solid phase peptide synthesis

Solid phase peptide synthesis ability

Solid phase peptide synthesis automation

Solid phase peptide synthesis basic strategies

Solid phase peptide synthesis cycles

Solid phase peptide synthesis equipment

Solid phase peptide synthesis restrictions

Solid phase polysaccharide synthesis

Solid phase synthesis

Solid phase synthesis (SPS

Solid phase synthesis SPOS)

Solid phase synthesis compounds

Solid phase synthesis inorganic based

Solid phase synthesis instruments-Automated

Solid phase synthesis of biopolymers

Solid phase synthesis of cysteine-containing peptides

Solid phase synthesis of oligosaccharides

Solid phase synthesis of peptides

Solid phase synthesis of polypeptides

Solid phase synthesis of protected peptide fragments

Solid phase synthesis organic based

Solid phase synthesis phosphoramidite nucleotide

Solid phase synthesis strategy for

Solid phase synthesis, nanomaterials

Solid phase synthesis, ozone

Solid- and Solution-Phase Techniques in Organic Synthesis

Solid-Phase Chemical Synthesis

Solid-Phase Domino Syntheses of Compound Collections

Solid-Phase Fischer Indole Synthesis

Solid-Phase Library Synthesis of Carbohydrates

Solid-Phase Madelung Indole Synthesis

Solid-Phase Oligosaccharide Synthesis Using Glycosyl Phosphates

Solid-Phase Organic Synthesis: Concepts, Strategies, and Applications. First Edition

Solid-Phase Peptide Synthesis The Merrifield Method

Solid-Phase Syntheses Involving Electrophiles in Solution

Solid-Phase Syntheses Involving Resin-Bound Electrophiles

Solid-Phase Synthesis (Combinatorial Methodology)

Solid-Phase Synthesis Oligomeric Molecules

Solid-Phase Synthesis Small Organic Molecules

Solid-Phase Synthesis as Developed by Merrifield

Solid-Phase Synthesis of 1,2,4-Thiadiazoles

Solid-Phase Synthesis of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles via Selective Cyclization

Solid-Phase Synthesis of 2,4,5-Trisubstituted Thiazoles

Solid-Phase Synthesis of A-Linked Glycopeptides

Solid-Phase Synthesis of Benzoxazoles

Solid-Phase Synthesis of Biologically Important Glycopeptides

Solid-Phase Synthesis of Complex Oligosaccharides

Solid-Phase Synthesis of Epothilone

Solid-Phase Synthesis of Pyrazolo

Solid-Phase Synthesis of the Blood Group H Determinant

Solid-Phase Synthesis with Glycosyltransferases

Solid-phase DNA synthesis

Solid-phase RNA synthesis

Solid-phase Supports for Organic Synthesis

Solid-phase Target-Oriented Total Synthesis of Natural Products

Solid-phase Wittig synthesis

Solid-phase catalysis peptide synthesis

Solid-phase heterocycle synthesis

Solid-phase macrocycle synthesis

Solid-phase multi-step syntheses

Solid-phase oligonucleotide synthesi

Solid-phase oligosaccharide synthesis acceptor-bound

Solid-phase oligosaccharide synthesis donor-bound

Solid-phase oligosaccharide synthesis linker

Solid-phase oligosaccharide synthesis, technique

Solid-phase oligosaccharide synthesis, technique development

Solid-phase organic synthesis

Solid-phase organic synthesis (SPOS

Solid-phase organic synthesis 2+2] cycloaddition reactions

Solid-phase organic synthesis Diels-Alder reaction

Solid-phase organic synthesis Suzuki couplings

Solid-phase organic synthesis amides

Solid-phase organic synthesis catalysed

Solid-phase organic synthesis cleavage protocols

Solid-phase organic synthesis cycloaddition

Solid-phase organic synthesis drug compounds

Solid-phase organic synthesis equipment

Solid-phase organic synthesis esterification

Solid-phase organic synthesis library development

Solid-phase organic synthesis natural products

Solid-phase organic synthesis overview

Solid-phase organic synthesis polymer supports

Solid-phase organic synthesis resins

Solid-phase organic synthesis solvents

Solid-phase peptide synthesis Fmoc-based

Solid-phase peptide synthesis PAM resin

Solid-phase peptide synthesis SPPS)

Solid-phase peptide synthesis Wang resin

Solid-phase peptide synthesis acid labile linkers

Solid-phase peptide synthesis advantages

Solid-phase peptide synthesis amino acid side chain protecting groups

Solid-phase peptide synthesis control

Solid-phase peptide synthesis coupling agents used

Solid-phase peptide synthesis coupling protected amino acids

Solid-phase peptide synthesis derived supports

Solid-phase peptide synthesis description

Solid-phase peptide synthesis linkers

Solid-phase peptide synthesis overview

Solid-phase peptide synthesis polymer-bound amino acid

Solid-phase peptide synthesis polystyrene-divinylbenzene

Solid-phase peptide synthesis preparation

Solid-phase peptide synthesis solvents

Solid-phase peptide synthesis spectrometry

Solid-phase peptide synthesis steps

Solid-phase peptide synthesis, general procedure

Solid-phase polyamide synthesis

Solid-phase synthesis 634 INDEX

Solid-phase synthesis acceptor-bound approach

Solid-phase synthesis advantages

Solid-phase synthesis alcohols

Solid-phase synthesis aldehydes

Solid-phase synthesis aliphatic amines

Solid-phase synthesis assessment, reaction conditions

Solid-phase synthesis automated

Solid-phase synthesis chemistry assessment

Solid-phase synthesis colorimetric tests

Solid-phase synthesis combinatorial exploitation

Solid-phase synthesis complex carbohydrates

Solid-phase synthesis continuous-flow

Solid-phase synthesis coupling methods

Solid-phase synthesis cyclic peptides

Solid-phase synthesis design

Solid-phase synthesis development

Solid-phase synthesis donor-bound approach

Solid-phase synthesis equipment

Solid-phase synthesis glycopeptides

Solid-phase synthesis kinetics

Solid-phase synthesis multiple reaction systems

Solid-phase synthesis ninhydrin test

Solid-phase synthesis nitridation

Solid-phase synthesis of oligonucleotides

Solid-phase synthesis of polypeptid

Solid-phase synthesis of unnatural amino acids and peptides

Solid-phase synthesis oligosaccharide libraries

Solid-phase synthesis optimization

Solid-phase synthesis overview

Solid-phase synthesis oxidation reactions

Solid-phase synthesis polymer-bound oximes

Solid-phase synthesis polymer-supported

Solid-phase synthesis polymers

Solid-phase synthesis protocols

Solid-phase synthesis purification

Solid-phase synthesis reaction conditions

Solid-phase synthesis reaction kinetics

Solid-phase synthesis reactors

Solid-phase synthesis reduction reactions

Solid-phase synthesis reproducibility

Solid-phase synthesis selection, reaction conditions

Solid-phase synthesis side products

Solid-phase synthesis site isolation

Solid-phase synthesis specific compounds

Solid-phase synthesis supports

Solid-phase synthesis target selection

Solid-phase synthesis thermodynamics

Solid-phase synthesis thio-oligosaccharides

Solid-phase synthesis validation

Solid-phase synthesis, branched

Solid-phase synthesis, of sugar fatty acid

Solid-phase synthesis, of sugar fatty acid monoesters

Solid-phase synthesis, types

Solid-phase, anhydride synthesis

Solid-phase/fluorous synthesis

Solide phase synthesis

Somatostatin solid-phase synthesis

Split-pool synthesis solid-phase

Strecker solid phase synthesis

Submonomer solid-phase synthesis

Supports in solid-phase synthesis

Suzuki solid-phase synthesis

Synthesis of Solid-Phase Discrete Libraries

Synthesis of Solid-Phase Pool Libraries

Synthesis of Trisubstituted Indoles on a Solid Phase

Synthesis of a pyrazole library using purification by solid phase extraction

Synthesis of a thiazole library using liquid- and solid-phase extractions

Synthesis peptides’ multiple solid phase

Synthesis solid phase interaction

Synthetic glycopeptides solid-phase synthesis

Technological Aspects of Automated Solid-Phase Oligosaccharide Synthesis

Tetrahydroquinoline solid phase synthesis

The Idea of Solid-Phase Synthesis

Thioglycosides solid phase synthesis

Tools for On-Bead Monitoring and Analysis in Solid-Phase Oligosaccharide Synthesis

Traceless solid-phase synthesis

Tripeptides solid phase synthesis

VIBRATIONAL SPECTROSCOPY FOR OPTIMIZATION OF SOLID-PHASE ORGANIC SYNTHESES

Vessels and Equipment for Solid-Phase Synthesis

Wang resin, solid-phase peptide synthesis and

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