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Merrifield solid-phase synthesis Fmoc protecting group

In a variation of the Merrifield solid-phase peptide synthesis, the amino group is protected by a fluorenylmethoxycarbonyl (FMOC) group. This protecting group is removed by treatment with a weak base such as the secondary amine piperidine. Write a balanced equation and propose a mechanism for this deprotection. [Pg.1186]


See other pages where Merrifield solid-phase synthesis Fmoc protecting group is mentioned: [Pg.190]    [Pg.90]    [Pg.200]    [Pg.1214]    [Pg.307]    [Pg.1905]    [Pg.1084]    [Pg.157]    [Pg.503]    [Pg.1077]    [Pg.69]    [Pg.213]    [Pg.468]    [Pg.332]    [Pg.201]    [Pg.214]    [Pg.214]    [Pg.6483]    [Pg.106]    [Pg.332]   
See also in sourсe #XX -- [ Pg.811 ]




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Fmoc

Fmoc group

Fmoc protecting group

Fmoc-protection

Group syntheses

Merrifield synthesis

Solid group

Solid-phase synthesi

Synthesis protection

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