Polymer-supported reactions

E. C. Blossey and D. C. Neckers, Eds., Solid Phase Synthesis, Halsted, New York, 1975 P. Hodge and D. C. Sherrington, Eds., Polymer-Supported Reactions in Organic Synthesis, Wiley-Interscience, New York, 1980. A comprehensive review of polymeric protective groups by J. M. J. Frechet is included in this book. 

Standard Suspension Polymerization Techniques, Appendix (1980). In Polymer-Supported Reaction in Organic Synthesis (P. Hodge and D. C. Sherington eds.), Wiley Chichester. 

Polymer-supported reactions are a relatively recent development in synthetic organic chemistry. In an ideal case a reagent is prepared as part of a polymer which is then poured onto a column. The reactant is then passed through the column in a suitable solvent and the product is obtained free of both starting material and other reagents and is simply isolated by evaporation of the solvent. Ideally the polymer should be easily recyclable. 

Hodge, P. and Sherrington, D.C. (Eds.), 1980, Polymer Supported Reactions in Organic Synthesis , John Wiley, New York. 

Method F (polymer-supported reaction) Amberlite IRA-400 (ArO form) (5 g), obtained by washing the resin with aqueous AiONa (0.25 M, 100 ml), followed by H20 (100 ml), is suspended in CH,C12 (20 ml) and refluxed for ca. 12 h. The resin is removed by filtration and is washed with CH2C12 (25 ml). Evaporation of the combined organic solutions yields the diaryloxymethane ( phenols having electron-withdrawing substituents may require 15 h reaction time for maximum yield). 

Polymer-Supported Reactions in Organic Synthesis, ed. P. Hodge, D.C. Sherrington, J. Wiley and Sons, Chichester, UK, 1980. 

Note 1 The easy separation of low-molar-mass reactants or products from the polymer-supported species is a great advantage of polymer-supported reactions. 

Note 2 Typical examples of polymer-supported reactions are (a) reactions performed by use of polymer-supported catalysts, (b) solid-phase peptide synthesis, in which 240... 

Hodge, P., Sherrington, D. C. Polymer-supported Reactions in Organic Synthesis. London John Wiley and Sons 1980... 

G. Swift, M. B. Freeman, Y. H. Paik, S. Wolk, and K. M. Yocom, ACS Biotech. SectetariatAbstr. (San Diego) (Spring 1994) 6th International Conference on Polymer Supported Reactions in Organic Chemistry (POC), Venice, Italy, June 19-23, 1994, Abstr., p. 1.13 and 3 5th TUPAC International Symposium on Macromolecules, Akron, Ohio, July 11—15, 1994, Abstr. 0-4.4-13, p. 615. 

To date the majority of polymer-supported chemistry is conducted only on a few solid support materials. Recently, it has been documented that specific solid-phase effects have significant impact on the success or failure of polymer-supported reactions.15 Considering the limitations of polystyrene, which is the standard material for most applications today, it becomes even more evident that innovations in the area of support materials will open the door to novel opportunities for polymer-supported chemistries. 

Hodge P, Sherrington DC (1980) Polymer-supported reactions in organic synthesis. Wiley, Chichester... 

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