Solid-Phase Domino Syntheses of Compound Collections

Solid-Phase Domino Syntheses of Compound Collections 

An interesting example of a domino reaction used in a sohd-phase strategy was reported by Meldal et al. [26], wherein the formation of fused (5-5), (5-6), (6-5), and (6-6) bicyclic ring systems was targeted using a common N-acyhminium 

N-acyliminium. (b) Examples of various heterocycles synthesized with this method. 

In contrast to the example described above, where the domino reaction occurs as the final step of the synthesis. Erase and Kapeller [27] used the domino reaction at the very beginning of the solid-phase synthesis of carmabinoids. In this 

Domino reactions are well suited to create compound collections with high structural diversity and molecular complexity. The well-designed reaction sequences are reliable and efficient methods, giving synthetic access to functionahzed small- to medium-sized molecules. These reactions are atom-economical and time-efficient, as they avoid multistep reactions, and reduce the number of tedious purification steps, which is a major advantage in the synthesis of large compound hbraries. Recent developments in scaHbld diversity synthesis utiHzing common substrates for domino reactions to create a plethora of novel ring systems clearly demonstrate 

---

Solid-Phase Domino Syntheses of Compound Collections 517... 

---