Solid-phase synthesis thio-oligosaccharides

SCHEME 14.18 Hindsgaul s solid-phase synthesis of thio-oligosaccharides. 

Hummel, G, Hindsgaul, O, Solid-phase synthesis of thio-oligosaccharides, Angew. Chem. Int. Ed., 38, 1782-1784, 1999. 

Although solid-phase chemistry is well developed, progress has not yet been fully extended to oligosaccharide chemistry, because of the high demands on the polymer support and the lack of powerful analytical tools for monitoring reactions on solid phases. The synthesis of an a(l-2)-linked pentamannose moiety has recently been reported (Scheme 45) [193] a Merrifield resin, a thio-linker, and a 2-0-acetyl protected mannosyl trichloroacetimidate were used. The glycosylation reaction was... 

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