Solid phase oligosaccharide synthesis SPOS

Initial attempts at solid-phase oligosaccharide synthesis (SPOS) were met with little success due to the limited range of glycosylation methods [98], It was not until much later when new methods emerged that SPOS was reexplored and has achieved remarkable success in the construction of complex oligosaccharides. 

Solid-phase organic synthesis (SPOS) is an established technique for generation of peptides,12 nucleotides,3 and more recently, carbohydrates (oligosaccharides).4-5 Supported syntheses of nonbiological oligomers6 16 and other small molecules17 21 have also been reported, reflecting the method s... 

Successful solid-phase oligosaccharide syntheses (SPOS) have been developed by several research groups [95,96,97,98,99,100,101,102,103,104,105], which exhibit the inherent advantages over solution phase synthesis, such as (i) higher reaction yields due to the use... 

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