RECENT ADVANCES IN SOLID-PHASE SYNTHESIS OF NATURAL PRODUCTS

RECENT ADVANCES IN SOLID-PHASE SYNTHESIS OF NATURAL PRODUCTS 

Solid-phase synthetic methods1,2 feature convenient purification procedures coupled with opportunities for automation.3 5 These attributes have been widely exploited to prepare libraries of small molecules via parallel and combinatorial approaches. A logical extrapolation of these efforts is the supported syntheses of larger, more complex natural products and natural product analogs. Such efforts are consistent with the pharmaceutical industry objectives behind most high-throughput syntheses since, historically, the unique properties of natural products have provided a fertile ground for 

There are several ways to prepare libraries of natural product derivatives on a solid phase. These include (a) total synthesis on the resin (b) derivation of supported natural products and (c) syntheses of analogs based on a natural product scaffold. This review will provide examples of all these approaches. 

---

Wilson, L.J., Recent advances in solid-phase synthesis of natural products, in Solid-Phase Organic Synthesis, Burgess, K., Ed., John Wiley Sons, New York, 2000, chap. 8. 

---