Glycosyl trichloroacetimidates automated solid-phase synthesis

Melean, L G, Love, K R, Seeberger, P H, Toward the automated solid-phase synthesis of oligoglucosamines systematic evaluation of glycosyl phosphate and glycosyl trichloroacetimidate building blocks, Carbohydr. Res., 337, 1893-1916, 2002. 

These results demonstrate that O-glycosyl trichloroacetimidate-based oligosaccharide synthesis on solid support may eventually become a valuable alternative to solution-phase synthesis because useful experience is available for the selection of the polymer support and choice of the linker system and the glycosyl donor. Further standardization of the building blocks and the protective group pattern will finally provide the yields and the anomeric control in order to successfully plan automated syntheses of oligosaccharides also in a combinatorial manner. 

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