New Trends in Solid-Phase Discrete Library Synthesis

4 NEW TRENDS IN SOLID-PHASE DISCRETE LIBRARY SYNTHESIS 

1 Solid Supports for High-Throughput Organic Synthesis Two-Dimensional SP Synthesis 

While the synthesis of an SP library has not yet been reported (187), the system has been carefully tested and the compatibility and reproducibility of dispensing various 

The synthesis of a model library of 100 amides from anhydrides on microchips has been described with quality control indicating excellent yields of pure amides and no cross-contamination of the wells (199). This test validated the chip structure, the seals of the system, and the electrohydrodynamic pumping system in the presence of solvents such as DMF and methanol and reagents such as the anhydrides, piperidine, and DIPEA. More challenging chemistries and larger libraries have also been presented. 

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