Combinatorial chemistry synthesis technologies

Reviews on properties of polymers in conjunction with solid-phase synthesis a) A.R. Vaino, K.D. Janda,/. Comb. Chem. 2000, 2, 579-596 b) E. R. Eelder in Combinatorial Chemistry and Technology Principles, Methods and Applications, Marcel Dekker Inc. (Eds. S. Miertus, G. Fassina) 1999, 35-51. c) B. Renneberg, J.W. Labadie, Chim. Oggi 1999, 17, 7-9 d) D.C. Sherrington, Chem. Commun. 1998, 2275-2286 e) P. Hodge, Chem. 

Resins, Linkers, and Reactions for Solid-Phase Synthesis of Organic Libraries. Felder, E. R. In Combinatorial Chemistry and Technology Miertus, S.. Fassina, G., Eds. Dekker New York, 1999, pp 35-51. 

One of the key technologies used in combinatorial chemistry is solid-phase organic synthesis (SPOS) [2], originally developed by Merrifield in 1963 for the synthesis of peptides [3]. In SPOS, a molecule (scaffold) is attached to a solid support, for example a polymer resin (Fig. 7.1). In general, resins are insoluble base polymers with a linker molecule attached. Often, spacers are included to reduce steric hindrance by the bulk of the resin. Linkers, on the other hand, are functional moieties, which allow the attachment and cleavage of scaffolds under controlled conditions. Subsequent chemistry is then carried out on the molecule attached to the support until, at the end of the often multistep synthesis, the desired molecule is released from the support. 

Combinatorial chemistry, developed in the mid-90s [227-229], allows the efficient synthesis of large sets of compounds with diverse features. It is therefore a widely used technology for creating screening libraries. For experimental screening, the most... 

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