Solid Phase Synthesis of aPNA

With a satisfactory synthesis of the nucleoamino acids in hand, we next developed a successful strategy for assembhng the a-heUcal peptide nudeic acids on a solid sup- 

an effective solid phase synthesis of aPNA 21-mers was successfully developed. The resulting SPPS protocols can be applied to aU four nucleoamino acids as well as a variety of ancillary amino acids leading to diverse aPNAs structures. 

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