Solid-phase synthesis oligosaccharide libraries

A linker originally designed for solid-phase synthesis of peptides is the backbone amide linker (11) (BAL), this anchoring approach has now been extended to the combinatorial synthesis of diverse amide [31], hydroxamate [32], oligosaccharide [33] and heterocyclic small molecule libraries [34-36]. 

As a consequence of the progress and success of diverse oligomer libraries, experts in combinatorial synthetic oligomers, glycopeptide and oligosaccharide libraries, RNA-and DNA-aptamers have each contributed their news in these fields, while novel experimental examples of the use of templates in combinatorial chemistry for the solid-phase synthesis of multiple core structure libraries provide some insight to praxis-relevant work. 

The Sulfoxide Glycosylation Method and its Application to Solid-Phase Oligosaccharide Synthesis and the Generation of Combinatorial Libraries... 

Solid-Phase Oligosaccharide Chemistry and Its Application to Library Synthesis... 

Seeberger PH, Haase WC. Solid-phase oligosaccharide synthesis and combinatorial carbohydrate libraries. Chem. Rev. 2000 100 4349-4394. 

Jonke S, Liu KG, Schmidt RR. Solid-phase oligosaccharide synthesis of a small library of W-glycans. Chem. Eur. J. 100. 2006 12 1274-1290. 

Solid-phase approaches may ease the product isolation and purification in the generation of larger oligosaccharide libraries. However, solid-support oligosaccharide synthesis requires thorough... 

Taylor, C. M. The sulfoxide glycosylation method and its application to solid-phase oligosaccharide synthesis and the generation of combinatorial libraries. Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries 2001,41 -65. 

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