PRACTICAL ASPECTS OF COMBINATORIAL SOLID-PHASE SYNTHESIS

PRACTICAL ASPECTS OF COMBINATORIAL SOLID-PHASE SYNTHESIS 

Solid-Phase Organic Synthesis Concepts, Strategies, and Applications, First Edition. Edited by Patrick H. Toy and Yulin Lam. 

Each chemical transformation that uses a series of building blocks is referred to as a combinatorial step the above example represents a synthesis with three combinatorial steps. A compoimd array prepared using only one set of building blocks is considered to be a parallel synthesis rather than a combinatorial synthesis. 

Combinatorial syntheses can be performed in two ways (i) split-and-pool (also referred to as the split-and-mix or the split-and-recombine method)and its variant directed sorting and (ii) parallel synthesis. A hybrid approach is the split-and-split technique.  

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