Solid phase oligosaccharide synthesis

One widely used method involving protected compounds is solid-phase synthesis (polymer-supponed reagents). This method has the advantage of requiring only a simple workup by filtration such as in automated syntheses, especially of polypeptides, oligonucleotides, and oligosaccharides. 

The application of solid-phase synthesis and automation has revolutionized much of the chemical and biochemical research related to peptides and nucleic acids.5 Thus, it is likely that successful methods to synthesize oligosaccharides and glycoconjugates... 

A major contribution to the use of glycosyl trichloroacetimidates in the solid-phase synthesis of oligosaccharides came from the group of T. Ogawa (Scheme 4.7).5... 

A linker originally designed for solid-phase synthesis of peptides is the backbone amide linker (11) (BAL), this anchoring approach has now been extended to the combinatorial synthesis of diverse amide [31], hydroxamate [32], oligosaccharide [33] and heterocyclic small molecule libraries [34-36]. 

Plante, O.J. Palmacci, E.R. Seebo-go-, P.H. (2001) Automated solid-phase synthesis of oligosaccharides. Science, 291, 1523-7. 

S. J. Danishefsky, K. F. McClure, J. T. Randolf, and R. B. Ruggeri, A strategy for the solid-phase synthesis of oligosaccharides. Science 260 1307 (1993) and references cited therein. 

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