Solid-phase organic synthesis alkaloids

The solid phase synthesis of many organic molecules utilizes carbodiimide mediated reactions. An example is the synthesis of l,4-benzodiazepine-2,5-dione using EDCCl in NMP in a key synthesis step. Often carbodiimides are used in the synthesis of complex proteins. A recent example is the synthesis of the tripeptide backbone of the novel immunosuppressent sanglifehrin A. In the synthesis of the marine alkaloid, variolin B, the formation of an annelated pyrimidine ring is achieved using a carbodiimide mediated cyclization process. 

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