Diversity Linker Units in Solid-Phase Organic Synthesis

7 DIVERSITY LINKER UNITS IN SOLID-PHASE ORGANIC SYNTHESIS 

Another class of linkers or more specifically cleavage strategies with potential application to DOS are those strategies that involve cleavage with concomitant ring closure 

Merrifield resin cross-linked with 1-2% divinylbenzene 

In the future, the ideas that underpin DOS, such as maximal chemical space coverage and efficient complex structure generation, will remain. However, we may also see DOS being used in a more focused way, directed toward the synthesis of novel or unusual chemical structures and architectures, and used more in the field of fragment-based drug discovery. Whatever directions DOS takes in the future, it is likely that solid-phase synthesis will remain integral to the field. 

Spaller, M. T. Burger, M. Fardis, P. A. Bartlett, Curr. Opin. Chem. Biol. 1997,1,47-53. 

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