Analytical methods used in solid-phase synthesis

Analytical methods used in solid-phase synthesis 

AnnualReports in Combinatorial Chemistry andMolecular Diversity, Vol. 1, pp. 59-68 1997ESCOM Science Publishers B. V. 

IR spectroscopy has been used to estimate the yield [10], The UV spectrophotometric quantitative measurement of Fmoc release from derivatized amino groups is still a very common method for measuring loadings [14], 

The importance of measuring and reporting yields cannot be overemphasized. The continued growth and success of solid-phase synthesis must be built on a solid foundation with rigorous characterization of solid supports, linkers and intermediates. 

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