Polymer-Supported and Solid-Phase Oligosaccharide Synthesis

3 Polymer-Supported AND Solid-Phase Oligosaccharide Synthesis 

Inspired by the success of Merrifield on solid-phase peptide synthesis, studies on solid-phase oligosaccharide syntheses were initiated in the early 1970s [96-98]. Using various approaches, some small ohgosaccharides were synthesized by different groups. However, the lack of reliable 

Polymer-supported liquid-phase synthesis was introduced for the preparation of oligosaccharides by Douglas, Whitfield and Krepinsky [99]. In their procedure, the carbohydrate is attached to the soluble polymer, poly(ethylene glycol)monomethyl ether (PEG), and all the chemical 

Synthetic strategies differ by binding either the glycosyl donor [105] or the glycosyl acceptor to the solid phase. A bidirectional approach [106], which allows for chain elongation in both directions, has also been reported. 

SCHEME S.36 Polymer-supported liquid-phase s3mthesis of heparin-mimic oligosaccharides. 

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