Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Scaling up

Reactor up-scaling during the screening process, for example from primary leads to secondary process parameter screening, is facilitated if a flexible combination of meso- and micro-scale reactors could be used in the same experimental set-up. [Pg.415]


When choosing the scale-up method, changes in other flow/power parameters and their impact on the process result must be considered. Figure 11 shows changes in important parameters for different scale-up bases. For example, scale-up based on same tip speed maintains the T / Ubut decreases P/ Uby 80%. T / Uis almost always increased on scale-up. Scale-up based on the same P/ Umeans a reduction in mixer speed by 66%, which also... [Pg.424]

These ideas and methods of preparative selective up-scale chromatography suggest that the use of new types of biosorbents and, in particular cellosorbents, and the application of theoretically based conditions for stepwise desorption of the components is an important new approach to preparative chromatography. [Pg.46]

Much effort has been devoted to the attempt to set up scales of a0 values of general applicability. Only very limited success has been achieved in this direction150 and it seems naive to suppose that any simple LFER analogous to the Hammett equation could be successful in connection with the orthos fleet, except in rather limited and special situations. On the whole the various essays at scales of o0 values have not involved sulfinyl or sulfonyl... [Pg.519]

Internal vs. External Numbering-up Scaling-out of Elements or Devices... [Pg.6]

The micro reactor was initially made as single-micro-channel version [15] and later as numbered-up (scale-out) three-micro-channel version (Figure 5.8) [16]. The data for both micro devices are given in the following. [Pg.586]

Unpublished laboratory results of PMV about high temperature treatment of RCP with suitable exhaust air and duration time showed a significant reduction of the volatile mineral oil constitutions of a magnitude of up to 98%. An up-scaling of those process stages or even an industrial implementation is not yet realised because the laboratory conditions cannot be transferred in an economical way. [Pg.406]

The reduction of a-hydroxynitriles to yield vicinal amino alcohols is conveniently accomplished with complex metal hydrides for example, lithium aluminum hydride or sodium borohydride [69]. However, it is still worth noting that a two-step chemo-enzymatic synthesis of (R)-2-amino-l-(2-furyl)ethanol for laboratory production was developed followed by successful up-scaling to kilogram scale using NaBH4/CF3COOH as reductant [70],... [Pg.115]

Liquid-liquid multiphasic catalysis with the catalyst present in the ionic liquid phase relies on the transfer of organic substrates into the ionic liquid or reactions must occur at the phase boundary. One important parameter for the development of kinetic models (which are crucial for up-scaling and proper economic evaluation) is the location of the reaction. Does the reaction take place in the bulk of the liquid, in the diffusion layer or immediately at the surface of the ionic liquid droplets ... [Pg.189]

The physical approach uses alternating current (ac-) dielectrophoresis to separate metallic and semiconducting SWCNTs in a single step without the need for chemical modifications [101]. The difference in dielectric constant between the two types of SWCNTs results in an opposite movement along an electric field gradient between two electrodes. This leads to the deposition of metallic nanotubes on the microelectrode array, while semiconducting CNTs remain in the solution and are flushed out of the system. Drawbacks of this separation technique are the formation of mixed bundles of CNTs due to insufficient dispersion and difficulties in up-scaling the process [102]. [Pg.18]

The introduction of the allylic silane moiety required for the intermolec-ular Hosomi-Sakurai reaction is depicted in Scheme 16. Following the formation of the enol triflate 97, a Stille coupling provided excess to the allylic alcohol 98 [51]. The allylic alcohol (98) was endowed with a phosphate leaving group for the subsequent allylic substitution. Utilizing a trimethylsilyl cuprate as nucleophile for the 5 2 reaction, the allylic phosphate was converted into the allylic silane 89. A useful substrate-induced diastereoselectivity in favour of (14i )-89 was encountered at small scale but decreased significantly upon up-scaling. [Pg.96]

Up-Scaling Photochemical Reactions (Braun, Jakob, Oliveros, Oiler do Nascimento). [Pg.182]

Is responsible for adequate promotion, up-scaling and presentation of progress and results. [Pg.58]

The service recipient has performed all up-scaling activities required for the improved wastewater process installation and currently effectively performs wastewater purification using the chemicals supplied on the basis of Chemical Leasing. [Pg.103]

This guidance provides recommendations to NDA and ANDA sponsors who intend to make changes to the product during the postapproval period. Changes include any change in components or composition of the product, the site of manufacture, the scale-up/scale-down of batch size, and/or the manufacturing process and/or equipment of an immediate-release oral formulation. [Pg.35]

TABLE 6 Changes in Batch Size Scale-Up/Scale-Down... [Pg.81]

The up-scaling from microreactor to small monoliths principally deals with the change of geometry (from powdered to honeycomb catalyst) and fluid dynamics (from turbulent flow in packed-bed to laminar flow in monolith channels). In this respect, it involves therefore moving closer to the conditions prevailing in the real full-scale monolithic converter, while still operating, however, under well controlled laboratory conditions, involving, e.g. the use of synthetic gas mixtures. [Pg.129]


See other pages where Scaling up is mentioned: [Pg.1620]    [Pg.77]    [Pg.77]    [Pg.177]    [Pg.178]    [Pg.239]    [Pg.2]    [Pg.229]    [Pg.252]    [Pg.223]    [Pg.189]    [Pg.190]    [Pg.202]    [Pg.10]    [Pg.11]    [Pg.389]    [Pg.244]    [Pg.517]    [Pg.357]    [Pg.358]    [Pg.332]    [Pg.362]    [Pg.73]    [Pg.374]    [Pg.69]    [Pg.75]    [Pg.84]    [Pg.360]    [Pg.130]    [Pg.695]   
See also in sourсe #XX -- [ Pg.233 ]




SEARCH



A Parenteral Drug Scale-Up

A Quasi-Continuous Granulation and Drying Process (QCGDP) to Avoid Scale-Up Problems

An Alternative Viewpoint For Scale-up

Analysis of Granulation Rate Processes and Implications for Scale-Up

Application of Scale-Up Methods in Pharmaceutical Engineering

Application of Scale-Up in Stirred Vessels

Aspects Concerning the Scale-up

Basic Ideas of Scale-up

Bioprocess Scale-Up

Bowens general scale-up method

Challenges in Developing and Scaling Up Chemical Processes

Chromatographic Scale-Up Procedures

Column Scale-Up

Comments on the Use of Simulation for Scale-up and Reactor Performance Studies

Common Scale-Up Factors

Consequences of Scale-up

Cost, Cleanliness, Scale-up, and Safety Considerations

Criteria for Scaling-Up Fermentors

Criteria of Scale-Up

Demonstration of Up-scaled Hydrogen Production by Palladium-based Membrane Reactors

Dimensionless Scale-up of Equipment

Direct scale-up

Easy Scale-Up

Economics and Scale-Up

Effect of Scale-up on Reactor Performance

Effects of Reactor Scale-up On Controllability

Electrode Materials and Scale-Up of Microbial Fuel Cells

Energy Required and Scale-up

Engineering Scale-up for Hydrogen Transport Membranes

Engineering and Scale-up Aspects

Equipment Scale-up and Modelling

Evaluation of scale-up coefficients

Example 3 Scaling up the System Application to Industrial Production

Example of Scale-up through Concurrent Modeling

Examples of Process Scale-Up

Experimental Demonstration of the Novel Process Concept in a Pilot-Scale Set-Up

Experimental methods for scale-up

Experiments necessary for scale-up

Extraction scale-up for mass transfer

Factors in equipment scale-up and design

Fermentation up-scaling

Fluidized Bed Scale-up

Fundamental Challenges of MicroChannel Scale-up

Further Scale-Up of O2 Production Systems

Gasifier Scale-Up

Heat Transfer Scale-Up Considerations

Hydrocyclone selection and scale-up

Immobilized Enzyme Bioreactor Design and Scale-Up

Industrial Scale-Up of Ortho Metalation Reactions

Integrating Strategy as General Scale-Up Concept in Bioprocessing

Laboratory data and scale-up

Method development scouting and scale-up

Microbiology of Salinispora tropica, Fermentation and Scale-up

Model experiments and scale-up

Modeling, Design, and Scale-up

NO2 and dust Classic for local to regional up-scaling

New Approach to the Scale-Up Problem in Tumbling Blenders

Optimization and Scale-Up of the DERA Reaction

Optimization of culture parameters and scale-up

Overall Scale-up Factor

Overcoming the Scale-up Challenges

Packed-Tower Scale-up

Parameters for Scale-up

Particle Motion and Scale-up

Practical Considerations in the Scale-Up of Powder-Filled Hard Shell Capsule Formulations

Practical aspects of reactor design and scale-up

Process Complexities in Scale-up

Process Development and Scale Up

Process Scale-up and Design Considerations

Process characteristic of the foam centrifuge and its scale-up

Process development and scale up for microbial PHA production

Prospects for Scale-Up

Reaction Scale-up

Reaction Simulation Studies as Aid for Further Scale-Up

Roller Compaction Scale-Up

Scale Methyl Acrylate Oxidation Reaction and Work-Up

Scale build up

Scale up of preparation

Scale up to humans

Scale-Up Approaches

Scale-Up Background

Scale-Up Based on Data from Existing Production Plant

Scale-Up Considerations for Biotechnology-Derived Products

Scale-Up Considerations in Granulation

Scale-Up From Bench to Plant

Scale-Up and Interpretation

Scale-Up and Monitoring of the Wet Granulation Process

Scale-Up for Heat Transfer

Scale-Up for Mixing

Scale-Up in Batch and Continuous-Flow

Scale-Up in Chemical Engineering

Scale-Up in Chemical and Bioprocess Engineering

Scale-Up in Co-Rotating Twin Screw Extruders

Scale-Up in Nature

Scale-Up in the Field of Granulation and Drying

Scale-Up of Analytical Methods

Scale-Up of Bench-Unit Kinetic Data

Scale-Up of Calcium Polyphosphate Fibers

Scale-Up of Centrate Clarity Limiting Applications

Scale-Up of Chromatography Columns

Scale-Up of Closed Loop Recycling Chromatography

Scale-Up of Drying Processes

Scale-Up of Electrochemical Reactors

Scale-Up of Elution Chromatography

Scale-Up of Enzymatic Processes

Scale-Up of Extrusion and Spheronization

Scale-Up of Film Coating

Scale-Up of Fluidized Bed Granulators

Scale-Up of Heterogeneous Systems

Scale-Up of High-Shear Mixer Granulators

Scale-Up of Kinetic Data

Scale-Up of PTC Systems

Scale-Up of Reactors

Scale-Up of Solid Dosage Forms Colleen E. Ruegger, Alan Royce, Matthew J. Mollan, Jr., Robert Wagner, Stephen Valazza, and Mark Mecadon

Scale-Up of Sonochemical Reactors

Scale-Up of Upstream Operations

Scale-Up of a Batch Reactor

Scale-Up of the Compaction and Tableting Process

Scale-Up of the Conventional Fluidized Bed Spray Granulation Process

Scale-Up on Process Performance and Product Quality

Scale-up

Scale-up

Scale-up Based on Energy

Scale-up Concerns

Scale-up Example for Storage

Scale-up Fermentation and Process Control of Bioisoprene

Scale-up Production

Scale-up Protocols

Scale-up Rules for Dilute Systems

Scale-up Studies in Asymmetric Transfer Hydrogenation

Scale-up Under Conditions of Partial Similarity

Scale-up and Differential Expansion

Scale-up and Operation

Scale-up and Production

Scale-up and Reproducibility

Scale-up and Testing of Mixers

Scale-up and pilot plants

Scale-up and post approval changes

Scale-up and post approval changes SUPAC)

Scale-up changes

Scale-up concept

Scale-up considerations

Scale-up correlation

Scale-up criteria

Scale-up design

Scale-up example

Scale-up factor

Scale-up from laboratory

Scale-up from pilot plant

Scale-up in Chemical Engineering. Marko Zlokarnik

Scale-up in reactor design

Scale-up issues

Scale-up law

Scale-up methods

Scale-up of Agitated Centrifugal Mixers

Scale-up of Batch Mixers

Scale-up of Bioreactors

Scale-up of Continuous Mixers

Scale-up of Cyclones

Scale-up of Electrolytic Reactors

Scale-up of HNL-Catalyzed Cyanohydrin Formation

Scale-up of Industrial Equipment

Scale-up of Ionic Liquid Synthesis

Scale-up of Manufacturing Expenses

Scale-up of Ribbon Mixers

Scale-up of Single Phase Non-Reactive Turbulent Stirred Tanks

Scale-up of Stirred-Tank Batch Reactors-Runaway Reactions

Scale-up of Two-Phase Reactions

Scale-up of Vent Size Package (VSP) Results

Scale-up of bubble column

Scale-up of bubble column reactors

Scale-up of chemical processes

Scale-up of crystallization process

Scale-up of crystallizers

Scale-up of liquid mixing systems

Scale-up of mechanical foam breakers

Scale-up of methods employing solvents

Scale-up of microwave-assisted organic synthesis

Scale-up of mixing systems

Scale-up of procedure

Scale-up of production

Scale-up of solvent-free methods

Scale-up of steam reforming technology

Scale-up of stirred vessels

Scale-up of suspension polymerization reactors

Scale-up of systems

Scale-up of the homogenization process

Scale-up on Actual Area

Scale-up on Cake Discharge

Scale-up on Rate

Scale-up on a Pilot SFC Unit

Scale-up possibilities

Scale-up principle

Scale-up problem

Scale-up procedures

Scale-up process

Scale-up ratios

Scale-up risk

Scale-up rule

Scale-up run

Scale-up strategies

Scale-up technical illustrations

Scale-up techniques

Scale-up technology

Scale-up to pilot plant

Scale-up, Flow Distribution and Interface to the Macroscopic World

Scale-up, mixing

Scale-ups

Scale-ups

Scaling Up Stirred Tanks

Scaling Up Stirred Tanks with Boiling

Scaling Up Test Results

Scaling Up Tubular Reactors

Scaling Up from Laboratory Data

Scaling Up of Microbial Fuel Cells

Scaling up Ionic Liquid Technology from Laboratory to Continuous Pilot Plant Operation

Scaling up of chromatographic separations

Scaling up of dispersion processes

Scaling up of trickle-bed reactors

Scaling up process

Scaling, Up or Down

Scaling-Up Of A Heterogeneous Photocatalytic Reactor With Radiation Absorption And Scattering

Scaling-Up of A Homogeneous Photochemical Reactor With Radiation Absorption

Scaling-Up of Thermoplastic Starch Extrusion

Scaling-Up the Coating Process

Scaling-up Fixed Bed Operations

Scaling-up of Ionic Liquid Synthesis

Scaling-up, criterion for

Scheme for the Scale-up of Electrochemical Reactors

Selection and Scale-up of Solids Batch Mixing Equipment

Short introduction to dimensional analysis and scale-up

Simple Dewatering and Torque Scale-Up

Smart Scale-up

Solution and Scale-up Issues

Special Scale-Up Considerations

Specialized (scale-up) culture systems

Stack Scale-Up

Stage V. Process Scale-up The Moment of Truth

Strategy for Scaling-up of SEC

Technology Transfer and Scale-Up

Testing and Scale-Up

The Effect of Scale-up on Mass Transfer

The Scale-Up Conundrum

The Scale-up of Real Batch Reactors

The Scaling-up Process

Theoretical Solutions of Fuel Cell Scaling-Up Issues

Transfer Coefficients and Interfacial Areas in Absorber Scale-Up

Understanding Scale-Up (-Down) in Chemical and Bioprocess Engineering

Up-Scaling Photochemical Reactions (Braun, Jakob, Oliveros, Oiler do Nascimento)

Up-scaling a Necessity

Up-scaling towards commercialization of polymer electrolyte-based dye-sensitized solar cells

Use of Dimensionless Groups in Scale-Up

Wall shear stress-flow characteristic curves and scale-up

© 2024 chempedia.info