Scale-Up in the Field of Granulation and Drying

Institute of Pharmaceutical Technology, Pharmacenter of the University of Basel, 

When the differential equations, or in general the equations, that govern the behavior of the system are known, they can be transformed into dimensionless forms. 

Both methods yield dimensionless groups, which correspond to dimensionless numbers [1], e.g.  

Reynolds number Re Froude number Fr Nusselt number Nu Sherwood number Sh Schmidt number Sc etc. [2] 

The classical principle of similarity can then be expressed by an equation of the form 

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Leueneberger H, Betz G, Allen M, Donsmark S, and Jones DH (2011) Scale-up in the field of granulation and drying, in Pharmaceutical Process Scale-up edited by M. Levin, Informa Healthcare, NY... 

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