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Scale-Up of Drying Processes

As a single-pot processor is often used for highly potent products, or more generally for contained production, it is important that also cleaning of the machine can be executed in a contained, automated fashion to eliminate the risk of operator exposure to the active product. [Pg.326]

Drying of the single-pot processor after the cleaning cycle to prepare the equipment for the next batch can be done using the system s own vacuum-drying system and jacketed bowl, making a separate drying unit redundant. [Pg.326]

A nice case study of an evaluation of a clean-in-place system on a pilot-scale single-pot processor is given in Ref (3). In this study it was proved that a complete changeover from one product to the next can take place in 2 hr. [Pg.326]


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