Immobilized Enzyme Bioreactor Design and Scale-Up

As noted earlier, enzymatic reactions rates not only depend on enzyme kinetics but also on other factors such as immobilization and mass transfer limitations. In addition, the amount of enzymes immobilized per weight of the support affects the 

Supercritical Fluids Technology in Lipase Catalyzed Processes 

For any ch ical process, scale-up involves the transfer of a lab-scale process to the production scale so the desired product can be produced in large quantities. In many cases, two different scale systans perform differently in the same conditions. This is due to different flow patterns and residence time distribution. Unlike other chemical processes, the scale-up of a chemical reactor is a complex and difficult process, where chonical similarity (conversion and selectivity) depends on the interaction of mass transfer, kinetics, and hydrodynamics. 

In immobilized bed reactors, the scale-up is also dependent on parameters related to mass transfer as mass transfer resistance is expected to increase with scale. Therefore, a similarity in the mass transfer coefficient, which is usually affected by the changes in flow rate, reactor diameter, and fluid properties, is important in these 

Abu-Reesh, I. M. 1997. Predicting the Performance of Immobilized Enzyme Reactors Using Reversible Michaelis-Menten Kinetics. Bioprocess Engineering 17 131-137. 

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