Scale-Up of Closed Loop Recycling Chromatography

In Section 7.1.2 it is shown that in case of high efficient chromatography the number of dimensionless parameters reduces and instead of Stanton and Pedet numbers the number of plates is the dominating parameter. In order to proof these findings for CLRC, Scherpian and Schembecker (2009) measured the elution profiles for three different process setups for which the number of plates, the loading factor, and the recycle number are constant. The characteristic data of these experiments are presented in the reference. 

In Section 7.1 it has been confirmed that elution profiles of chromatographic processes are congruent if the parameters of the dimensionless transport-dispersive model are identical based on these results Section 7.2 presents an optimization strategy for batch chromatography. A corresponding procedure is applicable for the theoretical optimization of recycle processes but it is very time consuming. An alternative for practical purposes is a scale-up based on experimentally optimized lab results or a practically satisfying process. 

These parameters ensure congruent elution profiles. In order to achieve the same production rate, the yield has to be constant  

Most parameters are different for each component. As already pointed out in Section 7.1.3, for all components the number of stages of the new column should be greater than or equal to the old one N N . Hence, the key component is = Nj. 

The column diameter depends on the expected production rate and the cycle time of the process  

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