Vascular cells

EDI), and water to produce a group of biodegradable PU foams. The interconnected pores varied in size from 10 to 2 mm in diameter. Rabbit bone-marrow stromal cells cultured on the materials for up to 30 days formed multilayers of confluent cells and were phenotypically similar to those grown on tissue culture PS. It supported the adherence and proliferation of both bone-marrow stromal cells and chondrocytes in vitro. In subdermal implants the investigators found that the material showed infiltration of both vascular cells and connective tissue. 

A 3D model of the fibrinogen-derived (very late antigen-4, VLA-4) inhibitor 4-[N -(2-methylphenyl)ureido]phenylacetyl-Leu-Asp-Val was derived from the X-ray structure of the related integrin-binding region of the vascular cell adhesion molecule-1 (VCAM-1). A 3D pharmacophore was generated with the program Catalyst, and a 3D search was performed in 8624 molecules from... 

Lagarde M, Gualde N, Rigaud M Metabolic interactions between eicosanoids in blood and vascular cells. Biochem J 1989 257 313. 

Baiillari G, Gendelman R, Gallo RC, Ensoli B (1993) The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the ROD amino acid sequence. Proc Natl Acad Sci USA 90(17) 7941-7945... 

Tse SYH, Mak IT, Weglicki WB et al. 1990. Chlorinated aliphatic hydrocarbons promote lipid peroxidation in vascular cells. J Toxicol Environ Health 31 217-226. 

IkB inhibitory protein kappa B lCAM-1 intercellular adhesion molecule 1 lL-1 interleukin-1 LDL low density lipoprotein MAPKs mitogen activated protein kinases MCP-1 macrophage chemotactic protein 1 M-CSF macrophage colony stimulating factor mmLDL minimally modified LDL NAC A-acetylcysteine NF-kB nuclear factor-kappa B oxLDL oxidised LDL PKC protein kinase C PMA phobol myristate acetate ROS reactive oxygen species TNF-a tumour necrosis factor alpha AM-1 vascular cell adhesion molecule 1... 

Selective inhibition of tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression by a novel flavonoid. Lack of effect on trascriptional factor NF-kB Arteriosclerosis, Thrombosis and Vascular Biology 16, 1501-8. 

NF-xB activates genes encoding MHC class I antigens, IL-1, TNFa, IL-6, the interleukin-2 (IL-2) receptor, some acute-phase proteins and the adhesion molecules, vascular cell adhesion molecule-1 (VCAM-1) (lademarco... 

Mazo IB, Gutienez-Ramos JC, Frenette PS, Hynes RO, Wagner DD, von Andrian UH. Hematopoietic progenitor cell rolling in bone marrow microvessels parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. J Exp Med 1998 188(3) 465-474. 

Frenette PS, Subbarao S, Mazo IB, von Andrian UH, Wagner DD. Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow. Proc Natl Acad Sci U S A 1998 95(24) 14423-14428. 

Simmons PJ, Masinovsky B, Longenecker BM, Berenson R, Torok-Storb B, Gallatin WM. Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells. Blood 1992 80(2) 388—395. 

Valente AJ, Graves DT, Vialle-Valentin CE, Delgado R, Schwartz CJ. Purification of a monocyte chemotactic factor secreted by nonhuman primate vascular cells in culture. Biochemistry 1988 27(11) 4162 1168. 

It has been proposed that NO mediates the myocardial depression associated with sepsis (F6, L14). NO synthesis induced by endotoxin blunts beta-adrenergic responsiveness (B2). In vivo, the use of NO synthase inhibitors led to conflicting results (M26), with a general decreased cardiac output and oxygen delivery being observed. NO synthase inhibition improved left ventricular contractility in endo-toxemic pigs but also increased ventricular afterloads, which ultimately is detrimental to cardiac function (H20). Possible sources of NO in the heart may be the vascular cells, the endothelial cells, and the cardiac myocytes (P6). 

C8. Carlos, T Swartz, R Kovach, N. L., Yee, E., Rosso, M., Osbom, L. C Rosso, G., Newman, B Lobb, R., and Harlan, J., Vascular cell adhesion molecule-1 (VCAM-1) mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells. Blood 76, 965-970 (1990). 

Prigent-Richard S, Cansell M, Vassy J et al (1998) Fluorescent and radiolabeling of polysaccharides binding and internalization experiments on vascular cells. J Biomed Mater Res... 

Haraldsen, G., Kvale, D., Lien, B., Farstad, I.N. and Brandtzaeg, P. (1996) Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (IGAM-1), and vascular cell adhesion molecule-1 (VGAM-1) in human microvascular endothelial cells. Journal of Immunology 156, 2558-2565. 

Halichlorine 11 is a structurally unique alkaloid that was isolated from the sponge Halichondria okadai and found to act as an inhibitor of the induction of vascular cell adhesion molecule (VCAM-1), a potential target in the development of drugs for the treatment of several vascular diseases. The strategies employed for the construction of its spiroquinolizidine unit are summarized in Scheme 106. 

A. Brunet, C. Privat, O. Stepien, M. David-Dufilho, J. Devynck, and M.A. Devynck, Advantages and limits of the electrochemical method using Nafion and Ni-porphyrin-coated microelectrode to monitor NO release from cultured vascular cells. Analusis 28, 469 (2000). 

Utilization of cell-specific peptide sequences in biomaterials enables the selective adhesion of certain cell types, even in the presence of a mixture of many cell types. As mentioned earlier, REDV promotes the adhesion of endothelial cells, but not other vascular cell types (Hubbell et al., 1991). This selectivity has great potential for endothelialization of vascular devices, where the growth of an endothelial cells, but not fibroblasts or smooth muscle cells, is desired. Another peptide sequence, KRSR, has been shown to selectively promote the adhesion of osteoblasts, which is useful in the rational design of better dental and orthopedic biomaterials (Dee et al., 1998). 

The endothelial vascular cells have an important role in maintaining cardiovascular health, producing nitric oxide (NO), a powerful vasodilator. NO also prevents the adhesion of leukocytes and platelets to the endothelial surface and platelet aggregation (Barringer and others 2008 Erdman and others 2007). 

Wang-Polagruto JF, Villablanca AC, Polagruto JA, Lee L, Holt RR, Schrader HR, Ensunsa JL, Steinberg FM, Schmitz HH and Keen CL. 2006. Chronic consumption of flavanol-rich cocoa improves endothelial function and decreases vascular cell adhesion molecule in hypercholesterolemic postmenopausal women. J Cardiovasc Pharmacol 47 Suppl 2 S177-186 discussion S206-209. 

There is a major difference between the role of free radicals in cancer and other pathologies such as cardiovascular diseases, hypertension, diabetes mellitus, etc. In contrast to the latter diseases where the sources of free radical overproduction are well established (vascular cells and macrophages in cardiovascular diseases and leukocytes in inflammation), the origin and the levels of free radical production in tumor cells are still uncertain. 

Simoncini T, De Caterina R, Genazzani AR (1999) Selective estrogen receptor modulators different actions on vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells. J Clin Endocrinol Metab 84 815-818... 

Somjen D, Kohen F, Jaffe A, Amir-Zaltsman Y, Knoll E, Stern N (1998) Effects of gonadal steroids and their antagonists on DNA synthesis in human vascular cells. Hypertension 32 39-45... 

Natalizumab (Tysabri ) is a recombinant humanized IgG4 mAb that binds to the a4-integrin subunit of a4(31 (VLA-4) and oA M (LPAM-1) integrins expressed on the surface of all leukocytes except neutrophils, and inhibits the a4-mediated adhesion of leukocytes to their respective receptors.103 104 The receptor for a4pi, vascular cell adhesion molecule-1 (VCAM-1), is expressed on activated endothelial cells and is... 

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