Intercellular adhesion molecules

Intercellular adhesion molecule-1, 128 Interfacial inhibition, 159 Intrinsic activity, 44-46 Intrinsic efficacy, 9, 45, 115 Inverse agonism, 49, 108 Inverse agonists... 

Key PMN, polymorphonuclear leukocytes EC, endothelial cell lymphs, lymphocytes CD, cluster of differentiation iCAM, intercellular adhesion molecule LFA-1, lymphocyte function-associated antigen-1 PECAM-1, platelet endothelial cell adhesion cell molecule-1. 

IkB inhibitory protein kappa B lCAM-1 intercellular adhesion molecule 1 lL-1 interleukin-1 LDL low density lipoprotein MAPKs mitogen activated protein kinases MCP-1 macrophage chemotactic protein 1 M-CSF macrophage colony stimulating factor mmLDL minimally modified LDL NAC A-acetylcysteine NF-kB nuclear factor-kappa B oxLDL oxidised LDL PKC protein kinase C PMA phobol myristate acetate ROS reactive oxygen species TNF-a tumour necrosis factor alpha AM-1 vascular cell adhesion molecule 1... 

Bradley, J.R., Johnson, D.R. and Fober, J.S. (1993). Endothelial activation by hydre en peroxide. Selective increases of intercellular adhesion molecule-1 and major histocompatibility complex class I. Am. J. Pathol. 142, 1598-1609. 

CD49 Cluster of differentiation 49 CD51 Known to be vitronectin receptor alpha chain CD54 Known to be Intercellular adhesion molecule-1 also known as ICAM-1... 

Haraldsen, G., Kvale, D., Lien, B., Farstad, I.N. and Brandtzaeg, P. (1996) Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (IGAM-1), and vascular cell adhesion molecule-1 (VGAM-1) in human microvascular endothelial cells. Journal of Immunology 156, 2558-2565. 

K. Drickamer, and A.-C. Roche, Oligolysine-based oligosaccharide clusters selective recognition and endocytosis by the mannose receptor and dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin, /. Biol. Chem., 278 (2003) 23922-23929. 

ICAM intercellular adhesion molecule t-MIAA tele methyl imidazole acetic acid... 

Oxidized LDL provokes an inflammatory response mediated by a number of chemoattractants and cytokines (e.g., monocyte colony-stimulating factor, intercellular adhesion molecule, platelet-derived growth factor, transforming growth factors, interleukin-1, interleukin-6). 

Ahmad, N. et al., Inhibition of macrophages with gadolinium chloride alters intercellular adhesion molecule-1 expression in the liver during acute endotoxemia in rats, Hepatology, 29, 728, 1999. 

Alveolar epithelial cells (AECs) are connected with each other by various epithelial cell-cell contacts (i.e., tight junctions, adherens junctions and others). These contacts comprise several groups of proteins, such as occludin, zonula occludens (ZO-1, -2, -3), claudins, tricellulin, E-cadherin and intercellular adhesion molecule-1 (ICAM-1) [13-15], Their regulation and interplay, which has influence on epithelial barrier properties, however, is largely unknown to date. 

Kang BH, Crapo JD, Wegner CD, Letts LG, Chang LY (1993) Intercellular adhesion molecule-1 expression on the alveolar epithelium and its modification by hyperoxia. Am J Respir Cell Mol Biol 9(4) 350-355... 

Zingarelli B, Salzman AL, Szabo C (1998) Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury. Circ Res 83 85-94... 

Morichika T, Takahashi HK, Iwagaki H, Yoshino T, Tamura R, Yokoyama M, et al Histamine inhibits lipopolysac-charide-induced tumor necrosis factor-01 production in an intercellular adhesion molecule-1- and B7.1-depen-dent manner. J Pharmacol Exp Ther 2003 304 624-633. 

Diacovo TG, Defougerolles AR, Bainton DF, Springer TA. A functional integrin ligand on the surface of platelets-intercellular-adhesion molecule-2. J Clin Invest 1994 94 1243-1251. 

Rat kidneys were perfused ex situ with phosphorothioate intercellular adhesion molecule (ICAM)-l AS-ODN and exposed to 30 min cold or warm ischaemia. After this time the kidneys were transplanted to syngeneic nephrectomized rats. Treatment with 10 mg antisense reduced the harmful effect of transplantation on renal function [132]... 

Cell adhesion protein (intercellular adhesion molecule) lCAM-1 is up-regulated. This protein plays a role in cell-cell adhesion and leukocyte migration. 

Abs, Antibodies CD, celiac disease EM, endomysial antibodies GFD, gluten-free diet HLA-DQ2, human leukocyte antigen ICAM, intercellular adhesion molecule IFN, interferon IL, interleukin Lab laboratory tTG, tissue transglutaminase antibodies. 

Selected adhesion molecules represent yet another antibody target. Adhesion molecules, such as LFA-1 (leukocyte function-associated antigen-1) and ICAM-1 (intercellular adhesion molecule 1), play central roles in promoting migration of inflammatory cells to the sites of damage. Such activities underlie many of the symptoms of conditions such as rheumatoid arthritis. Inhibition of adhesion molecule function by administration of antibodies raised against them may, therefore, demonstrate therapeutic potential in some instances. 

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