Macrophage-colony-stimulating factor

M-CSF serves as a growth, differentiation and activation factor for macrophages and their precursor cells. It is also known as CSF-1. This cytokine is produced by various cell types (Table 10.5). The mature form is a glycoprotein containing three potential N-linked glycosylation sites. Three related forms of human M-CSF have been characterized. All are ultimately [Pg.269]

The biologically active form of M-CSF is a homodimer (two identical subunits). These homodimers can exist as integral cell surface proteins, or may be released from their producer cell by proteolytic cleavage, thus yielding the soluble cytokine. The M-CSF receptor is a single-chain, heavily glycosylated, polypeptide of molecular mass 150 kDa. [Pg.270]

Murine macrophage colony-stimulating factor obtained from mouse L cells can be purified more efficiently on a large scale by HPLC in the presence of sodium dodecyl sulfate. The adsorption on hydroxylapatite gel is dependent on the presence of sodium dodecyl sulfate [197]. [Pg.275]

Term to UltraLink granulocyte- macrophage colony-stimulating factor Concept type PRODUCT... [Pg.734]

Normalized term Granulocyte-macrophage colony-stimulating factor—Cangene Synonyms ... [Pg.734]

Granulocyte-macrophage colony -stimulating factor—Cangene... [Pg.734]

When the user clicks View Granulocyte-macrophage colony-stimulating factor—Cangene in IDdb, the UltraLink jumps to the associated entry in IDDB (Fig. 31.3B). [Pg.742]

TUMOR NECROSIS FACTOR ALPHA STIMULATES THE GROWTH OF THE CLONOGENIC CELLS OF ACUTE MYELOBLASTIC LEUKEMIA IN SYNERGY WITH GRANULOCYTE / MACROPHAGE COLONY -STIMULATING FACTOR... [Pg.743]

Granulocyte-macrophage colony stimulating factor 127 amino acids E. coll Improved bone marrow transplant Approved for sale... [Pg.464]

IkB inhibitory protein kappa B lCAM-1 intercellular adhesion molecule 1 lL-1 interleukin-1 LDL low density lipoprotein MAPKs mitogen activated protein kinases MCP-1 macrophage chemotactic protein 1 M-CSF macrophage colony stimulating factor mmLDL minimally modified LDL NAC A-acetylcysteine NF-kB nuclear factor-kappa B oxLDL oxidised LDL PKC protein kinase C PMA phobol myristate acetate ROS reactive oxygen species TNF-a tumour necrosis factor alpha AM-1 vascular cell adhesion molecule 1... [Pg.14]

Rajavashisth, T.B., Andalibi, A., Territo, M.C., Berliner, J.A., Navab, M., Fogelman, A.M. and Lusis, A.J. (1990). Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low density-lipoproteins. Nature 344, 254—257. [Pg.111]

M-CSF Monocyte/macrophage colony-stimulating factor MCt Tryptase-containing mast cell MCtc Tryptase- and chymase-containing mast cell MDA Malondialdehyde MDGF Macrophage-derived growth factor... [Pg.284]

GCSF, granulocyte colony stimulating factor GMCSF, granulocyte-macrophage colony stimulating factor SQ, subcutaneous IV, intravenous AML, acute myeloid leukemia. [Pg.1471]

GMCSF granulocyte macrophage-colony stimulating factor... [Pg.1492]

GM-CSF Granulocyte-macrophage colony-stimulating factor ID Identification infectious disease... [Pg.1555]

Cheng SS, Lai JJ, Lukacs NW, Kunkel SL. Granulocyte-macrophage colony stimulating factor up-regulates CCR1 in human neutrophils. J Immunol 2001 166 1178-1184. [Pg.83]

Dale DC, Liles WC, Llewellyn C, Price TH. Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on neutrophil kinetics and function in normal human volunteers. Am J Hematol 1998 57 7-15. [Pg.85]

Kim MS, Day CJ, Morrison NA. MCP-1 is induced by receptor activator of nuclear factor-a B ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation. J Biol Chem 2005 280(16) 16163-16169. [Pg.190]

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