Vascular smooth muscle cells transduction

Ahn, H.Y., Hadizadeh, K.R., Seul, C., Yun, Y.P., Vetter, H., and Sachinidis, A., Epigallocathe-chin-3-gallate selectively Inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of ai-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172), Mol. Biol. Cell, 10, 1093, 1999. 

Proliferative effects of homocysteine have been demonstrated in several in vitro studies. Brown et al. (61) found that homocysteine activates the MAP kinase signal transduction pathway in vascular smooth muscle cells. 

Cook, J. L., Mills, S. J., Naquin, R., et al. 2006. Nuclear accumulation of the ATI receptor in a rat vascular smooth muscle cell line effects upon signal transduction and cellular proliferation. J Mol Cell Cardiol 40 696-707. 

Ishida, T., Ishida, M., Suero, J., et al. 1999. Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src. J Clin Invest 103 789-797. 

Touyz, R.M., and Schifftin, E.L. 2000. Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol. Rev. 52 639-672. 

Mechanochemical Transduction by Vascular Smooth Muscle Cells (VSMCs)... 

Li C, Xu Q. Mechanical stress-induced signal transductions in vascular smooth muscle cells. Cell Signal. 2000 12 435 145. 

Wrenn RW, Raeuber CL, Herman LE, Walton WJ, Rosenquist TH (1993) Transforming growth factor-beta signal transduction via protein kinase C in cultured embryonic vascular smooth muscle cells. In vitro Cell Dev Biol 29A 73-76... 

Since endothelial and vascular smooth muscle cells can rapidly synthesize and metabolize histamine, a possible homeostatic role for histamine in cardiovascular physiology has been suggested (Gross et al., 1984). Catecholamine-stimulated histamine release from vascular tissue (Schayer, 1960 Rand et al., 1982) may function to attenuate the effect of catecholamines on heart rate, contractility, and coronary resistance (Gross et ai, 1984 Giacomini and Reis, 1986). Histamine may exert its effects on catecholamine activity by forcing an uncoupling of the P-receptor from the transductional protein, Gs (Levi et ai, 1991). 

Connective tissue in the vascular system plays an important role in maintenance of the intact vascular wall. Vitamins E and C influence the extracellular matrix (ECM) by their antioxidant functions. They bind to specific enzymes and act as cofactors and regulators with consequent modulation of vascular smooth muscle cell (VSMC) signal transduction and gene expression. The ability of vitamins E and C to influence VSMC proliferation, differentiation, and ECM production is important in the maintenance of intact vascular wall and in the repair of atherosclerotic lesions. Actively proliferating cells, but not quiescent cells, are susceptible to ascorbic acid, which inhibits cell division and promotes necrosis through its action on S-phase progression. 

Hashim, S., Y.Y. Liu, R. Wang, and M.B. Anand-Srivastava. 2002. Streptozotocin-induced diabetes impairs G-protein linked signal transduction in vascular smooth muscle. Mol. Cell. Biochem. 240 57-65. 

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