Integrin expression

Einheber, S., Milner, T., Giancotti, F. and Salzer, J. Axonal regulation of Schwann cell integrin expression suggests a role for a6 04 in myelination. /. Cell. Biol. 123 1223-1235, 1993. 

Saintier D, Burde MA, Rey JM, Maudelonde T, de Vernejoul MC, Cohen-Solal ME (2004) 17beta-estradiol downregulates beta3-integrin expression in differentiating and mature human osteoclasts. J Cell Physiol 198 269-276... 

Natalizumab (Tysabri ) is a recombinant humanized IgG4 mAb that binds to the a4-integrin subunit of a4(31 (VLA-4) and oA M (LPAM-1) integrins expressed on the surface of all leukocytes except neutrophils, and inhibits the a4-mediated adhesion of leukocytes to their respective receptors.103 104 The receptor for a4pi, vascular cell adhesion molecule-1 (VCAM-1), is expressed on activated endothelial cells and is... 

J.D. Aplin, A. Sattar, and A.P. Mould. Variant choriocarcinoma (BeWo) cells that differ in adhesion and migration on fibronectin display conserved patterns of integrin expression. J Cell Sci. 103 (Pt 2) 435 144 (1992). 

Hdlig P, et al. Novel RGD lipopeptides for the targeting of liposomes to integrin-expressing endothelial and melanoma cells. Protein Eng 2004 17 433. 

Hieken TJ, Ronan SG, Farolan M, et al. Beta 1 integrin expression a marker of lymphatic metastases in cutaneous malignant melanoma. Anticancer Res 1996 16(4B) 2321-2324. 

Flatten M, Wick W, Wild-Bode C, et al. Transforming growth factors beta(l) [TGF-beta(l)] and TGF-beta(2) promote glioma cell migration via up-regula-tion of alpha (V)beta(3) integrin expression. Biochem Biophys Res Commun 2000 268(2) 607-611. 

W. Cal, X. Zhan, Y. Wu, X. Chen, A thiol-reactive F-labeling agent, N-[2-(4-i8F-f uorobenzamido)ethyl]maleimide, and synthesis of RGD peptide-based tracer for PET imaging of alpha-v-beta-3-integrin expression, J. Nucl. Med. 47 (2006) 1172-1180. 

C F]-Galacto-RGD-PET Imaging of avPa integrin expression [ F]-Fluorocholine-PET Imaging of prostate cancer... 

TGF-P — Fibrosis and wound healing in vivo, influences integrin expression and differentiation — Macrophages, T cells, B cells, epithelial cells... 

Ammon C, Meyer SP, Schwarzfischer L, Krause SW, Andreesen R, Kreutz M. Comparative analysis of integrin expression on monocyte-derived macrophages and monocyte-derived dendritic cells. Immunology 2000, 100, 364—369. 

Hughes, D.E., Salter, D.M., Dedhar, S., et al. (1993) Integrin expression in human bone. Journal of Bone and Mineral Research 8 527-533... 

In addition to mediating cell adhesion, it has been demonstrated that integrin expression by osteoblasts determines their phenotypic expression (see the section Osteoblasts The Bone-Forming Cells ). For example, addition of either soluble concentrations of RGD (Moursi et al, 1996) or antibodies of the integrin pair avp() (Moursi et al., 1997) to confluent osteoblast cultures, blocked initiation and formation of mineral nodules these results provided evidence that integrin-fibronectin interactions leading to extracellular matrix development play a crucial role in osteoblast function (Moursi etal., 1996,1997). 

Sinha, R. K., and Tuan, R. S., Regulation of human osteoblast integrin expression by orthopaedic implant metals. Bone 18, 451-457 (1996). 

Orthopedic and dental implant materials bioceramics, 145-146 chemical modifications, 147-148 comparing mechanical properties of, and bone, 146 conventional, 127 costs, 126-127 current materials, 145-148 fate of implanted device, 140-141 integration into surrounding tissue, 127 integrin expression on osteoblasts, 144 integrins, 143-144 metals, ceramics, and polymers, 145 next generation, 127,148-159... 

Wozniak M, Fausto A, Carron CP, Meyer DM, Hruska KA. Mechanically strained cells of the osteoblast hneage organize their extracellular matrix through unique sites of alpha V beta 3-integrin expression. J Bone Miner Res. 2000 15 1731-1745. 

Integrins are members of a laige family of transmembrane proteins that act as receptors for cell-adhesion molecules. Integrins are heteromeric proteins. The type of integrin expressed on the surface of a cell determines what kind of adhesion molecules and hence which cells can be bound. 

Burtea, C., Laurent, S., Murariu, O., et al. (2008) Molecular imaging of integrin expression in atherosclerotic plaques with a mimetic of RGD peptide grafted to Gd-DTPA. Cardiovascular Research, 78, 148-157. 

Coles B, Bloodsworth A, Clark SR, Lewis MJ, Cross AR, Freeman BA, O Donnell VB. Nitrolinoleate inhibits superoxide generation, degranulation, and integrin expression by human neutrophils. Circ. Res. 2002 91 375-381. 

Bertomeu, M. C., Gallo, S., Lauri, D., Haas, T. A., Orr, F. W., Bastida, E. and Buchanan, M. R. (1993). IL-l-induced cancer cell/endothelial cell adhesion in vitro and its relationship to metastasis in vivo role of vessel wall 13-HODE synthesis and integrin expression. Clin Exp. Metastasis 77, 243-250. 

Herzberg F, Schoning M, Schirner M, et al. IL-4 and XNF-a induce changes in integrin expression and adhesive properties and decrease the lung-colonizing potential of HX-29 colon carcinoma cells. Clin Exp Metastasis 1996 14 165-75. 

---