Integrins binding

Mi LX, Fischer S, Chung B et al (2006) Self-assembling protein hydrogels with modular integrin binding domains. Biomacromolecules 7 38 7... 

Petrie TA, Garcia AJ (2009) Extracellular matrix-derived ligands for seledive integrin binding to control cell function. In Puleo DA (ed) Biological interactions on materials surfaces. Springer, New York... 

A 3D model of the fibrinogen-derived (very late antigen-4, VLA-4) inhibitor 4-[N -(2-methylphenyl)ureido]phenylacetyl-Leu-Asp-Val was derived from the X-ray structure of the related integrin-binding region of the vascular cell adhesion molecule-1 (VCAM-1). A 3D pharmacophore was generated with the program Catalyst, and a 3D search was performed in 8624 molecules from... 

Keselowsky BG, Collard DM, Garcia AJ (2003) Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion. J Biomed Mater Res 66A 247-259... 

Monaghan, Sean, Griffith-Johnson, David, Matthews, Ian and Bradley, Mark (2001). Solid-phase synthesis of peptide-dendrimer conjugates for an investigation of integrin binding. Arkivoc, 2001, (Part (x)), 46-53. http //eprints.soton.ac.uk/19576/... 

CIBl = Calcium- and integrin-binding protein DGBP = D-Galactose binding protein Pmrl = plasma membrane ATP-ase related protein. 

Within each of these adhesion molecule families, membership has been defined largely by amino-acid sequence similarity, which is reflected in common structural features. Consequently, distinct binding requirements also characterize each family. For example, cadherins interact in a Ca2+-dependent, usually homophilic manner. Binding of the members of the Ig family is Ca2+-independent and, although frequently homophilic, can be heterophilic. Integrin binding is also divalent cation-dependent (Ca2+, Mg2+) but always heterophilic. 

Leong, J. M., Fournier, R. S., and Isberg, R. R. (1990). Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein. EMBO J. 9,1979-1989. 

Hart SL, Harbottle RP, Cooper R, et al. Gene delivery and expression mediated by an integrin-binding peptide. Gene Ther 1995 2(8) 552-554. 

Rooney, M. M., Farrell, D. H., van Hemel, B. M., de Groot, P. G., and Lord, S. T. (1998). The contribution of the three hypothesized integrin-binding sites in fibrinogen to platelet-mediated clot retraction. Bbod 92, 2374-2381. 

Integrin binding (GPO)2 GFOGER (GPO)s 21 1Q7D 2.10 Variable Emsley et al, 2004... 

Pfaff, M., Reinhardt, D. P., Sakai, L. Y., and Timpl, R. (1996). Cell adhesion and integrin binding to recombinant human fibrillin-1. FEBS Lett. 384, 247-250. 

Spring, F. A., Parsons, S. F., Ortlepp, S., et al. Intercellular adhesion molecule-4 binds alpha 4 beta 1 and alpha V-family integrins through novel integrin-binding mechanisms. Blood 98 458-466, 2001. 

Davis GE. The Mac-1 and pl50,95 beta 2 integrins bind denatured proteins to mediate leukocyte cell-substrate adhesion. Experimental Cell Research 1992, 200, 242-252. 

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