Vascular smooth muscle cells phenotypes

Spin, J. M., Maegdefessel, L., and Tsao, P. S. 2012. Vascular smooth muscle cell phenotypic plasticity Focus on chromatin remodelling. 95, 147-55. 

Zhang, Y. Ramos, K. S. (1997). The induction of proliferation vascular smooth muscle cell phenotypes by benzo(a)pyrene does not involved mutational activation of ras genes. 

Ragolia, L., et al. (2003). Prostaglandin D2 synthase inhibits the exaggerated growth phenotype of spontaneously hypertensive rat vascular smooth muscle cells. J. Biol. Chem. 278, 22175-81. 

Song J, Wan Y, Rolfe BE, Campbell JH, Campbell GR (1998) Effect of estrogen on vascular smooth muscle cells is dependent upon cellular phenotype. Atherosclerosis 140 97-104... 

Reddy, M.A., Villeneuve, L.M., Wang, M., Lanting, L. and Natarajan, R. (2008) Role of the lysine-spedfic demefhylase 1 in the proinfiammatory phenotype of vascular smooth muscle cells of diabetic mice. Circulation Research, 103, 615-623. 

Rennick RE, Connat JL, Burnstock G, Rothery S, Severs NJ, Green CR Expression of connexin 43 gap junctions between cultured vascular smooth muscle cells is dependent upon phenotype. Cell Tissue Res 1993 271 323-332. 

Bascands, J. L., Girolami, J. R, Troly, M., et al. 2001. Angiotensin II induces phenotype-dependent apoptosis in vascular smooth muscle cells. Hypertension 38 1294-1299. 

Fukuda, N., Hu, W. Y., Satoh, C., et al. 1999. Contribution of synthetic phenotype on the enhanced angiotensin II-generating system in vascular smooth muscle cells from spontaneously hypertensive rats. J Hypertens 17 1099-1107. 

Birukov KG, Shirinsky VP, Stepanova OV, Tkachuk VA, Hahn AW, Resink TJ, Smirov VN. Stretch affects phenotype and proliferation of vascular smooth muscle cells. Mol Cell Biochem. 1995 144 131-139. 

The in vitro experiments that utilize cultures of vascular smooth muscle cells (VSMC) require initial isolation of primary aortic VSMC from adult mice (5-8 weeks old). Because adult vascular cell culmres undergo significant phenotypic modulation with prolonged culture it is necessary to continuously generate and maintain low-passage cultures (<6). 

Restenosis occurring after balloon angioplasty and coronary artery stent implantation is characterized by an extensive neoin-timal proliferation of vascular smooth muscle cells and the formation of extracellular matrix [38, 39]. This change in smooth muscle cell phenotype from a contractile to a synthetic state was shown to be correlated with an increased synthesis of the potent mitogen endothelin-1 (ET-1) in the vessel wall [40]. Increased synthesis of ET-1 has been demonstrated to occur after pressure trauma to the vessel wall in experimental animal models and in hu-... 

Pidkovka, N.A. et al. Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitro. Circ. Res. 101 (2007) 792-801. 

Xiang D, Huang D, Gai L and Liu H (2000) Relationship between expression of type III collagen and phenotype of vascular smooth muscle cells in neointimal of stented coronary artery. Chin Med J 113 324-327. 

Cook CL, Weiser MCM, Schwartz PE, Jones CL, Majack RA (1994) Developmentally timed expression of an embryonic growth phenotype in vascular smooth muscle cells. Circ Res 74 189-196... 

Goodman LV, Majack RA (1989) Vascular smooth muscle cells express distinct transforming growth factor-P receptor phenotypes as a function of cell density in culture. J Biol Chem 264 5241-5244... 

Cell Culture in Microchannels MicroChannel systems can be used to generate continuous gradient of some growth factors in order to study the optimal proliferation and differentiation conditions of some cells. They can also be used to micropattem the cell culture surface area. Cells cultivated in microchannels are used to study cellular properties within fluidic environments, especially the impact from shear stress. For example, the geometry of the microchannel affects cell growth, orientation, and phenotype control of vascular smooth muscle cells. Smooth muscle cells cultured in wider... 

Qu M, Liu B, Wang H, Yan Z, Shen B and Jiang Z (2007). Frequency-dependent phenotype modulation of vascular smooth muscle cells under cyclic mechanical strain , J. Vase. Res., 44,345-353. 

Hayashi K, Takahashi M, Nishida W, et al. Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids. Circ Res 2001 89 251-258. 

Bingley JA, Hayward IP, Campbell JH and Campbell GR. Arterial heparan sulfate proteoglycans inhibit vascular smooth muscle cell proliferation and phenotype change in vitro and neointimal formation in vivo. J Vase Surg 28 308-18, 1998. 

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