Bone marrow stromal cells

EDI), and water to produce a group of biodegradable PU foams. The interconnected pores varied in size from 10 to 2 mm in diameter. Rabbit bone-marrow stromal cells cultured on the materials for up to 30 days formed multilayers of confluent cells and were phenotypically similar to those grown on tissue culture PS. It supported the adherence and proliferation of both bone-marrow stromal cells and chondrocytes in vitro. In subdermal implants the investigators found that the material showed infiltration of both vascular cells and connective tissue. 

Birnbaum T, Roider J, Schankin CJ, Padovan CS, Schichor C, Goldbrunner R, Straube A (2007) Malignant gliomas actively recruit bone marrow stromal cells by secreting angiogenic cytokines. J Neurooncol 83 241-247... 

Van Den Heuvel R, Schoeters G, Vanderborght O. 1987. Radiosensitivity to 241 Am of bone marrow stromal cells in offspring of contaminated mice. In Age-related factors in radionuclide metabolism and dosimetry. Netherlands Kluwer Academic Publishers, 201-208. 

The murine stromal-derived factor-la (SDF-1)/CXCL12 was originally cloned from a cDNA library derived from the bone marrow stromal cell tine ST2 by a method to clone cDNAs that carry specific amino terminal signal sequences, such as those encoding intercellular signaling-transducing molecules... 

Cherry, Yasumizu R, Toki J, et al. Production of hematopoietic stem cell-chemotactic factor by bone marrow stromal cells. Blood 1994 83(4) 964-971. 

Simmons PJ, Masinovsky B, Longenecker BM, Berenson R, Torok-Storb B, Gallatin WM. Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells. Blood 1992 80(2) 388—395. 

Vande Broek I, Asosingh K, Vanderkerken K, et al. Chemokine receptor CCR2 is expressed by human multiple myeloma cells and mediates migration to bone marrow stromal cell-produced monocyte chemotactic proteins MCP-1, -2, and -3. Br J Cancer 2003 88 855-862. 

Silk fibers or monolayers of silk proteins have a number of potential biomedical applications. Biocompatibility tests have been carried out with scaffolds of fibers or solubilized silk proteins from the silkworm Bombyx mori (for review see Ref. [38]). Some biocompatibility problems have been reported, but this was probably due to contamination with residual sericin. More recent studies with well-defined silkworm silk fibers and films suggest that the core fibroin fibers show in vivo and in vivo biocompatibility that is comparable to other biomaterials, such as polyactic acid and collagen. Altmann et al. [39] showed that a silk-fiber matrix obtained from properly processed natural silkworm fibers is a suitable material for the attachment, expansion and differentiation of adult human progenitor bone marrow stromal cells. Also, the direct inflammatory potential of silkworm silk was studied using an in vitro system [40]. The authors claimed that their silk fibers were mostly immunologically inert in short and long term culture with murine macrophage cells. 

Main producer cells Bone marrow stromal cell Macrophages Fibroblasts Lymphocytes Myoblasts Osteoblasts Monocytes Fibroblasts Endothelial cells Macrophages T-lymphocytes Fibroblasts Endothelial cells... 

Yamaguchi, K., et. al., Activation of the aryl hydrocarbon receptor/transcription factor and bone marrow stromal cell-dependent pre-B cell apoptosis, J. Immunol., 158, 2165,1997. 

Lavin, A., Hahn, D., and Gasiewicz, T. A., Expression of functional aromatic hydrocarbon receptor and aromatic hydrocarbon nuclear translocator proteins in murine bone marrow stromal cells, Arch. Biochem. Biophys., 352, 9, 1998. 

Dorshkind K, 1990. Regulation of hemopoiesis by bone marrow stromal cells and their products. Ann Rev Immnnol 8 111... 

CSF-1 is synthesized by many different cell types including fibroblasts, endothelial cells, bone marrow stromal cells, osteoblasts, keratinocytes, astrocytes, myoblasts and, during pregnancy, under the control of estrogen and progesterone, by uterine epithelial cells. Circulating CSF-1 (ti/2 = 10 min) is synthesized by endothelial cells and smooth muscle cells. It is primarily cleared by CSF-lR-mediated internalization and destruction by Kupffer cells. Thus the number of sinusoidally located macrophages actually determines the concentration of the cytokine... 

The AhR is expressed in bone marrow stromal cells [14] and human hematopoietic stem cells [15] and upon agonist binding the receptor translocates to the nucleus, resulting in altered transcriptional expression such as increased CYPlAl [16] and resulting in reactive oxygen species [17]. Nonpharmaceutical compounds such as TCDD, benzo(a)pyrene and benzene have been shown to induce hematotoxicity using this mechanism in vivo and in vitro [18, 19]. 

Zhu. H.. Li. Y. and Trush, M.A. (1995) Characterizatoin of benzo[a]pyrene quinine-induced toxicity to primary cultured bone marrow stromal cells from DBA/2 mice potential role... 

Pereira, A. and Dean, B. (2006) Clozapine bioactivation induces dose-dependent, drug-specific toxicity of human bone marrow stromal cells a potential in vitro system for the study of agranulocytosis. Biochemical Pharmacology, 71, 783—793. 

Bone marrow stromal cells Epithelial cells... 

NT035 Khaldoyanidi, S., L. Sikora, I. Orlovskaya, V. Matrosova, V. Kozlov, and P. Sriramarao. Correlation between nicotine-induced inhibition of hematopoiesis and decreased CD44 expression on bone marrow stromal cells. Blood 2001 98(2) 303-312. 

Monticone, M., Liu, Y.,Tonachini, L., et al. (2004), Gene expression profile of human bone marrow stromal cells determined by restriction fragment differential display analysis, /. Cell. Biochem, 92(4), 733-744. 

Di Nicola, M., Carlo-Stella, C., Magni, M., et al. (2002), Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli, Blood, 99(10), 3838-3843. 

Chen, J., Li, Y., Zhang, R., Katakowski, M., Gautam, S.C., Xu, Y., Lu, M., Zhang, Z., Chopp, M. (2004). Combination therapy of stroke in rats with a nitric oxide donor and human bone marrow stromal cells enhances angiogenesis and neurogenesis. Brain Res, 1005,21-8. 

Zang et al. developed a peptide-based polyurethane scaffold for tissue engineering. LDI was reacted with glycerol and upon reaction with water produced a porous sponge due to liberation of CO2. Initial cell growth studies with rabbit bone marrow stromal cells showed that the polymer supported cell growth. 

On the other hand, hydroquinone (3 pmol/L) prevented the staurosporine-induced apoptosis of HL-60 and the IL-3-dependent murine myeloblastic (32D) cell line it also prevented apoptosis of the 32D cells observed in the absence of IL-3. The myeloperoxidase inhibitor indomethacin opposed the effect of hydroquinone on staurosporine-induced apoptosis of HL-60 cells (Hazel et al., 1995, 1996b). Pretreatment of human leukaemia cells ML-1 with buthionine sulfoximine (100 pmol/L for 24 h), in order to decrease their glutathione content, increased the susceptibility of these cells to hydroquinone-induced inhibition of differentiation caused by phorbol acetate pretreatment with l,2-dithiole-3-thione, which induces reduced glutathione synthesis, prevented the differentiation inhibition of hydroquinone. Treatment of DBA/2 mice with 1,2-dithiole-3-thione, which increased the activity of quinone reductase of bone-marrow stromal cells by 50%, decreased the susceptibility of these cells towards hydroquinone (Trush et al., 1996). 

IL-11 Bone marrow (stromal cells) B-cell progenitors and others Differentiation... 

Keating, A., Berkham, L. and Filshie, R.A. (1998) Phase I study of the translation of genetically marked autologous bone marrow stromal cells. Hum. Gene Ther., 9, 591-600. 

This bioceramic material is made of hydroxyapatite that has been inoculated with bone marrow stromal cells. (Mauro Fermariello/Photo Researchers, Inc.)... 

Chuah, M. K., Van Damme, A., Zwinnen, H., Goovaerts, I., Vanslembrouck, V., Collen, D. and Vandendriessche, T. (2000). Long-term persistence of human bone marrow stromal cells transduced with factor VUI-retroviral vectors and transient production of therapeutic levels of human factor VIII in nonmyeloablated immunodeficient mice. Hum. Gene Ther. 11, 729-738. 

Krebsbach, P. H., Zhang, K., Malik, A. K. and Kurachi, K. (2003). Bone marrow stromal cells as a genetic platform for systemic delivery of therapeutic proteins in vivo Human factor IX model. J. Gene Med. 5, 11-17. 

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