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Kaposi’s sarcomas

Liposomal encapsulation of DOX or DNR Preferred anthracycline delivery to the tumor Breast cancer, ovarian cancer, AIDS-related Kaposi s sarcoma, multiple myeloma (pegylated liposomal DOX). Breast cancer (uncoated liposomal DOX). AIDS-related Kaposi s sarcoma, acute mye-loblastic leukemia, multiple myeloma, non-Hodgkin s lymphomas (uncoated liposomal DNR)... [Pg.95]

Cytokines and biological response modifiers represent a broad class of therapeutic agents that modify the hosts response to cancer or cancer therapies. The enormous body information about their clinical uses and their side effects is beyond the scope of this essay that can only give illustrative examples. For an up-to-date information the reader can resort to reference [5]. As many as 33 different interleukins are known and the list continues to grow IL-2 used in the treatment of kidney cancer is one example. Interferon alpha is used for chronic myelogenous leukeia, hairy cell leukaemia and Kaposi s sarcoma. Interferons are also used in the treatment of chronic infections such as viral hepatitis. Tumor necrosis factor (alpha), G/GM/M-CSF, and several other cellular factors are used in treatment of various cancers. Many of these cytokines produce serious side effects that limit their use. [Pg.268]

Ovarian cancer, breast cancer, AIDS-related Kaposi s sarcoma... [Pg.586]

Hodgkin s disease, lymphocytic lymphoma, histiocytic lymphoma, mycosis fungoides, testicular cancer, Kaposi s sarcoma, breast cancer Acute leukemia, combination therapy for various cancers... [Pg.586]

Haverkos HW, Pinsky PF, Drotman DP, etal Disease manifestation among homosexual men with acquired immunodeficiency syndrome a possible role of nitrites in Kaposi s sarcoma. Sex Transm Dis 12 203-208, 1985 Haverkos HW, Kopstein AN, Wilson H, et al Nitrite inhalants history, epidemiology, and possible links to AIDS. Environ Health Perspect 102 858-861, 1994 Hernandez-Avila CA, Ortega-Soto HA, Jasso A, et al Treatment of inhalant-induced psychotic disorder with carbamazepine versus haloperidol. Psychiatr Serv49 812— 815, 1998... [Pg.307]

The list of vimses involved in other human cancers includes hepatitis B, which is associated with hepatocellular carcinoma human papilloma viruses with cervical, penile and some anal carcinomas human T-cell lymphotropic virus type 1 associated with adult T-cell leukaemia/lymphoma syndrome and HIV with Kaposi s sarcoma. [Pg.72]

Liposomal doxorubicin is an irritant, not a vesicant, and is dosed differently from doxorubicin, so clinicians need to be very careful when prescribing these two drugs. The pharmacokinetics of liposomal doxorubicin are best described by a two-compartment model, with a terminal half-life of 30 to 90 hours.20 Liposomal doxorubicin has shown significant activity in the treatment of breast and ovarian cancer, along with multiple myeloma and Kaposi s sarcoma. Side effects include mucositis, myelosuppression, alopecia, and palmar-plantar erythrodysesthesia. The liposomal doxorubicin may be less cardiotoxic than doxorubicin. [Pg.1289]

Kledal TN, Rosenkilde MM, Coulin F, et al. A broad-spectrum chemokine antagonist encoded by Kaposi s sarcoma-associated herpesvirus. Science 1997 277 1656-9. [Pg.27]

Burger M, Burger JA, Hoch RC, Oades Z, Takamori H, Schraufstatter IU. Point mutation causing constitutive signaling of CXCR2 leads to transforming activity similar to Kaposi s sarcoma herpesvirus-G protein-coupled receptor. 1 Immunol 1999 163(4) 2017-2022. [Pg.51]

Gershengom MC, Geras-Raaka E, Varma A, Clark-Lewis I. Chemokines activate Kaposi s sarcoma-associated herpesvirus G protein-coupled receptor in mammalian cells in culture. J Clin Invest 1998 102(8) 1469-1472. [Pg.330]

Bais C, Santomasso B, Coso O, et al. G-protein-coupled receptor of Kaposi s sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature 1998 391(6662) 86-89. [Pg.330]

Yang TY, Chen SC, Leach MW, et al. Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi s sarcoma. J Exp Med 2000 191 (3) 445 154. [Pg.331]

Guo HG, Sadowska M, Reid W, Tschachler E, Hayward G, Reitz M. Kaposi s sarcoma-like tumors in a human herpesvirus 8 ORF74 transgenic mouse. J Virol 2003 77(4) 2631-2639. [Pg.331]

Intron A interferon a-2b Schering-Plough Hairy cell leukemia, genital warts, AIDS-related Kaposi s sarcoma, hepatitis C, hepatitis B, malignant melanoma, follicular lymphoma in conjunction with chemotherapy... [Pg.694]

Browning, PJ, Roberts, DD, Zabrenetzky, V, Bryant, J, Kaplan, M, Washington, RH, Panet, A, Gallo, RC, and Vogel, T, 1994. Apolipoprotein E (ApoE), a novel heparin-binding protein inhibits the development of Kaposi s sarcoma-like lesions in BALB/c nu/nu mice. J Exp Med 180, 1949-1954. [Pg.340]

Hairy cell leukaemia Renal cell carcinoma Basal cell carcinoma Malignant melanoma AIDS-related Kaposi s sarcoma Multiple myeloma Chronic myelogenous leukaemia Non-Hodgkin s lymphoma... [Pg.226]

See other pages where Kaposi’s sarcomas is mentioned: [Pg.21]    [Pg.540]    [Pg.238]    [Pg.238]    [Pg.235]    [Pg.99]    [Pg.120]    [Pg.584]    [Pg.271]    [Pg.291]    [Pg.18]    [Pg.229]    [Pg.240]    [Pg.119]    [Pg.24]    [Pg.373]    [Pg.128]    [Pg.832]    [Pg.850]    [Pg.1256]    [Pg.1289]    [Pg.1292]    [Pg.1293]    [Pg.1373]    [Pg.330]    [Pg.135]    [Pg.139]   
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AIDS-related Kaposi’s sarcoma

Kaposi sarcoma

Kaposi’s sarcoma associated herpesvirus

Kaposi’s sarcoma associated herpesvirus KSHV)

Kaposi’s sarcoma herpesvirus

Kaposi’s sarcoma herpesvirus G-protein-coupled receptor

Kaposi’s sarcoma-associated

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