Vascular smooth muscle cells differentiation

Martin KA, Rzucidlo EM, Merenick BL, etal, The mTOR/p70 S6KI pathway regulates vascular smooth muscle cell differentiation. Am J Physiol Cell Physiol 2004 286(3) C507—C5I7,... 

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Wohus, A.M. et al.. Embryonic stem cells as a model to study cardiac, skeletal muscle, and vascular smooth muscle cell differentiation. Methods Mol Biol, 2002.185 127-56. 

S1P2 Ubiquitous Gj/O. Gq, G12/13 Migration, vascular development, differentiation of vascular smooth muscle cells... 

Shackelton LM, Mann DM, Millis AJ 1995 Identification of a 38kDa heparin-binding glycoprotein (gp38k) in differentiating vascular smooth muscle cells as a member of a group of proteins associated with tissue remodeling. J Biol Chem 270 13076—13083... 

Nausch LWM, Lecloux I, Bonev AD, Nelson MT, Dostmann WR (2008) Differential patterning of cGMP in vascular smooth muscle cells revealed by single GFP-linked biosensors. Proc Natl Acad Sci USA 105 365-370... 

Moraghan T, Antoniucci DM, Grenert JP, Sieck GC, Johnson C, Miller VM, Fitzpatrick LA (1996) Differential response in cell proliferation to beta estradiol in coronary arterial vascular smooth muscle cells obtained from mature female versus male animals. Endocrinology 137 5174-5177... 

Hirschi , Minnich BN, Moore LK, Burt JM Oleic acid differentially affects gap junction-mediated communication in heart and vascular smooth muscle cells. Am J Physiol 1993 265 C1517-0 526. 

Reusch HP, Zimmermann S, Schaefer M, Paul M, Moelling K (2001) Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells. J Biol Chem 276(36)33630-33637... 

Lauzier MC, Page EL, Michaud MD, Richard DE. 2007. Differential regulation of hypoxia-inducible factor-1 (HIF-1) through receptor tyrosine kinase transactivation in vascular smooth muscle cells. Endocrinology 148 4023-4031. 

Davidson, J. M LuValle, P, Zoia, O., Quaglino, D., and Giro, M. (1997). Ascorbate differentially regulates elastic and collagen biosynthesis in vascular smooth muscle cells and skin fibroblasts by prolranslational mechanisms. /. Bibf. CAfjji. 272, 345-352. 

Ky currents in vascular smooth muscle cells have diverse properties. The existence of multiple Ky currents within a given artery, or of the differential distribution between different vascular beds, is unknown. More understanding of the properties and distribution of individual Ky channels may shed some light on their physiological role, and remains an important goal for future research. Inhibition of Ky channels may be involved in hypoxia and vasoconstrictor-induced membrane depolarization. The predicted modulation of Ky channels by vasodilators and vasoconstrictors will also be an important area of future investigation. 

In addition, the low affinity NT receptor (p75), which is abundantly expressed by vascular smooth muscle cells at the time of differentiation and innervation (Schecterson and Bothwell, 1992), is also implicated by genetic analysis (Hilbert et al., 1991 Nemoto et al., 1994). 

MacNaul, K. L., and Hutchinson, N. I. (1993). Differential expression of iNOS and cNOS mRNA in human vascular smooth muscle cells and endothelial cells under normal and inflammatory conditions. Biochem. Biophys. Res. Commun. 196, 1330-1334. 

Gollasch, M., Haase, H., Ried, C., Lindschau, C., Miethke, A., Morano, I., Luft, F.C., and Haller, H. (1997) Expression of L-type calcium channels depends on the differentiated state of vascular smooth muscle cells. FASEB J., (In Press)... 

Shanahan CM, Weisseberg PL, Metcalf JC (1993) Isolation of gene markers of differentiated and proliferating vascular smooth muscle cells. Circ Res 73 193-204... 

Takahashi Y, Imanaka T, Takano T (1996) Spatial and temporal pattern of smooth muscle cell differentiation during develoment of the vascular system in the mouse embryo. Anat Embryol Berl 194 515-526... 

Pauletto P, Sarzani R, Rappelli A, Chiavegato A, Pessina AC, Sartore S (1994) Differentiation and growth of vascular smooth muscle cells in experimental hypertension. Am J Hypertens 7 661-674... 

Owens GK (1996) Role of mechanical strain in regulation of differentiation of vascular smooth muscle cells. Circ Res 79 1054-1055... 

Papakonstantinou E, Roth M, Block LH, Mirtsou-Fidani V, Argiridis P, Karakiulakis G. The differential expression of hyaluronic acid in the layers of human atheromatic aortas is associated with vascular smooth muscle cell proliferation and invasion. Atheroscl 1998 138 79-89. 

Another possibility deserving consideration is that some of the phytoestrogen effects may be attributable to properties that do not involve estrogen receptors, such as effects on enzymes, protein synthesis, cell proliferation, angiogenesis, calcium transport, Na /K adenosine triphosphatase, growth factor action, vascular smooth muscle cells, lipid oxidation, and cell differentiation. Some of these properties will be further discussed. 

Swanson J. M. and Volkow N. D. 2003. Serum and brain concentrations of methylphenidate Implications for use and abuse. Neurosci. Biobehav. Rev. 27 615-621 Tabet F., Savoia C., Schiffrin E. L. and Touyz R. M. 2004. Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats. J. Cardiovasc. Pharmacol. 44 200-208 Tanda G., Pontieri F. E., Frau R. and Di C. G. 1997. Contribution of blockade of the noradrenaline carrier to the increase of extracellular dopamine in the rat prefrontal cortex by amphetamine and cocaine. Fur. J. Neurosci. 9 2077-2085... 

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