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Vascular cell adhesion molecule VCAM-1 inhibitor

Halichlorine 11 is a structurally unique alkaloid that was isolated from the sponge Halichondria okadai and found to act as an inhibitor of the induction of vascular cell adhesion molecule (VCAM-1), a potential target in the development of drugs for the treatment of several vascular diseases. The strategies employed for the construction of its spiroquinolizidine unit are summarized in Scheme 106. [Pg.65]

A 3D model of the fibrinogen-derived (very late antigen-4, VLA-4) inhibitor 4-[N -(2-methylphenyl)ureido]phenylacetyl-Leu-Asp-Val was derived from the X-ray structure of the related integrin-binding region of the vascular cell adhesion molecule-1 (VCAM-1). A 3D pharmacophore was generated with the program Catalyst, and a 3D search was performed in 8624 molecules from... [Pg.411]

See other pages where Vascular cell adhesion molecule VCAM-1 inhibitor is mentioned: [Pg.57]    [Pg.133]    [Pg.90]    [Pg.149]    [Pg.774]    [Pg.1633]    [Pg.345]    [Pg.143]    [Pg.2017]    [Pg.187]    [Pg.1450]   
See also in sourсe #XX -- [ Pg.57 ]



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Adhesion molecules

Cell adhesion

Cell adhesion inhibitors

Cell adhesion molecule

Cell adhesion molecule inhibitors

Cell adhesive

Inhibitor molecules

VCAMs

Vascular adhesion molecule 1 (VCAM

Vascular cell adhesion molecule

Vascular cells

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