Umbilical

Typically, a Subsea Field Development or Subsea Satellite Development would consist of a cluster of special subsea trees positioned on the seabed with produced fluids piped to the host facility. Water injection, as well as lift gas, can be provided from the host facility. Control of subsea facilities is maintained from the host facility via control umbilicals and subsea control modules. 

The most basic subsea satellite is a single Subsea Wellhead with Subsea Tree, connected to a production facility by a series of pipelines and umbilicals. A control module, usually situated on the subsea tree, allows the production platform to remotely operate the subsea facility (i.e. valves, chokes). 

As the first well is being drilled the template is connected to the host facility with flowlines, umbilicals and risers. A Chemical Injection Umbilical will also typically be laid to the template or subsea facility and connected to a distribution manifold. 

Only one set of pipelines and umbilicals (as with the template) are required from the manifold back to the host facility, saving unnecessary expense. Underwater manifolds are becoming very popular as they offer a great deal of flexibility in field development and can be very cost effective. 

With the electro-hydraulic system the signals, power and hydraulic supplies are sent from a Master Control Station (or MCS) on the host facility down Control Umbilicals (Fig 10.36) to individual Junction Boxes on the seabed or subsea structure. 

Figure 10.36 Electro-Hydraulic Control Umbilical Bundle...

Nabel-. umbilical, navel, -kraut, n. navel wort. 

Human umbilical vein endothelial cells (HUVEC) express the isoforms ECE-la, -lb, -Id and ECE-2. In these cells, ET-1 is secreted via both a constitutive and a regulated pathway. The ratio of released ET-1 big-ET-1 is 4 1. About 80% of the ET-1 is secreted at the abluminal cell surface of endothelial cells. ECE-isoforms are abundantly expressed on the cell surface of endothelial cells and to a lower level also on vascular smooth muscle cells. In atherosclerotic lesions of vessels, however, ECE expression in smooth muscle cells is upregulated. ECE isoforms expressed in smooth muscle cells contribute significantly to the generation of mature ET in normal and in particular atherosclerotic vessels. 

Expression (Human) Tissues Leukocytes, thymus, spleen, liver, ovary Cells PBLs, neutrophils,T-cells, dendritic cells, mast cells, eosinophils, macrophages, leukocytes Tissues spleen, small intestine, placenta, lung smooth muscle, Cells bronchial smooth muscle, CD34+ hemapoietic progenitor cells, monocytes, macrophages, mast cells, eosinophils, neutrophils, PBLs, human umbilical vein endothelial cells Tissues, heart, skeletal muscle, spleen, brain, lymp node, adrenal medulla, lung, human pumonary/ saphenous vein Cells monocytes, macrophages, mast cells, eosinophils, cardiac muscle, coronary artery, PBLs... 

The adherence and proliferation of human umbilical vein endothelial cells (HUVECs) were evaluated on the fabricated PCLA scaffold. Results showed that the HUVECs were adhered and proliferated well on the small-diameter-fiber fabrics (0.3 and 1.2 mm in diameter), whereas markedly reduced cell adhesion, restricted cell spreading, and no signs of proliferation were observed on the large-diameter-fiber fabric (7 mm in diameter). That may be due to the high-surface-density fibers provide an extremely high surface/volume ratio, which favors cell attachment and proliferation. 

Warty diskeratoma elevated papule with a keratotic umbilicated center, occasionally found on non-sun-exposed skin... 

Schmaier AH, Kuo A, Lundberg D, Murray S, Cines DB The expression of high molecular weight kininogen on human umbilical vein endothelial cells. J Biol Chem 1988 263 16327-16333. 

Human umbilical vein cells Flow chamber 0-1 Nm-2 [46]... 

The initial component of the PTX-induced contraction is selectively inhibited by ouabain, whereas the second component is rather potentiated by it (77). A similar inhibitory effect of ouabain on the contractile response to PTX is observed in the umbilical artery, which is devoid of adrenergic innervation 18). 

Placental transfer of trichloroethylene occurs in animals. Trichloroethylene inhaled by pregnant sheep and goats, at levels used to induce analgesia and anesthesia, is rapidly distributed into the fetal circulation, with peak levels occurring approximately 40-50 minutes after maternal exposure (Helliwell and Hutton 1950). The concentration of trichloroethylene in umbilical vein blood was comparable to that found in the maternal carotid artery. 

Kaneko et al. (1993) have described a group of lipophilic ascorbic-acid analogues that have been studied in cultured human umbilical vein endothelial cells that were first incubated with test drug and then exposed to lipid hydroperoxides. Although ascorbate itself did not protect the endothelial cells, derivatives like CV3611 protected. Pretreatment was necessary. CV3611 was synergistic with vitamin E. The authors concluded that these lipophilic antioxidants incorporate into endothelial cell membranes where they are effective inhibitors of lipid peroxidation. In contrast, lipophobic antioxidants were not effective in their hands (Kaneko et al., 1993). 

HUVEC Human umbilical vein endothelial cell... 

Nair, X. Contractile responses of guinea pig umbilical arteries to various hallucinogenic agents. Res Commun Chem Pathol Pharmacol 9 535-542, 1974. 

II Umbilical cord, joint, and mucosal tract bleeding Prolonged prothrombin (PT) and activated partial thromboplastin time (aPTT) Specific assay for prothrombin... 

X Umbilical cord, joint, and muscle bleeding Prolonged PT and aPTT Normal thrombin time Prolonged Russel s viper venom Specific factor X assay... 

XIII Umbilical cord, intracranial, and joint bleeding recurrent miscarriages, impaired wound healing Normal PT, aPTT, thrombin time, bleeding time Specific factor XIII assay... 

Most experience is with HLA-matched donors umbilical cord blood transplantation is being evaluated... 

Experience with HSCT in adult patients with SCD is very limited. Umbilical cord blood and hematopoietic cells from nonmatched donors are alternatives, but use is limited.6,33... 

Compare the different types of HCTs, specifically (a) the types of donors (i.e., autologous and allogeneic), (b) the source of hematopoietic cells (i.e., umbilical cord, peripheral blood progenitor cells, and bone marrow), and (c) the type of preparative regimen (i.e., myeloablative and nonmyeloablative). 

Umbilical cord blood, peripheral blood progenitor cells (PBPC) and bone marrow can serve as the source of hematopoietic cells. The optimal cell source differs based on the donor and recipient characteristics but has not been clearly identified for all patients. 

The type of HCT performed depends on a number of factors, including type and status of disease, availability of a compatible donor, patient age, performance status, and organ function. In addition to bone marrow, hematopoietic cells may be obtained from the peripheral blood progenitor cells (PBPCs) and umbilical cord blood. The essential properties of the hematopoietic cells are their ability to engraft, the speed of engraftment, and the durability of engraftment.1... 

Transplant with umbilical cord blood (UCB) offers an alternative stem cell source to patients who do not have an acceptable matched related or unrelated donor. When allogeneic hematopoietic cells are obtained from UCB, the cord blood is obtained from a consenting donor in the delivery room after birth and delivery of the placenta.32 The cord blood then is processed, a sample is sent for HLA typing, and the cord blood... 

Allogeneic hematopoietic cell transplantation A transplantation of hematopoietic (blood-forming) bone marrow, peripheral blood, or umbilical cord blood involving one person as a donor and another person as a recipient. 

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