Human umbilical vein endothelia cell HUVEC

CB4 Endothehal caimabinoid receptor. A subtype that has been identified in arteries and human umbilical vein endothelial cells (HUVEC) and is present in vascnlar endothelium. It can be activated by anandamide, N-arachidonyl dopamine, virohdamine, and abnormal cannabidiol bnt not by the 2-AG and classical CB/CBj cannabinoid agonist to induce endothelium-dependent vasodilation that is present in CBj and CBj wild-type and mutant... 

Cationic chitosan was used to form a complex with oversulfated fucoidan (OFD), which is known to have antiangiogenic properties. The charge of the nanoparticles could be controlled by the ratio of both polyelectrolytes. It was found that at a pH of 6.5 the nanoparticles with a positive surface charge could open the tight junctions between Caco-2 cells, thereby allowing the transport of OFD, which is otherwise very poorly absorbed by the intestinal endothelium due to its high hydrophilicity. OFD could then inhibit the angiogenesis of human umbilical vein endothelial cells (HUVECs). 

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