Umbilical metastasis

Fig. 10.9. Umbilical metastasis. Sister Mary Josefs nodule is a peritoneal implant to the umbilicus. In this patient, a solid 1.5-cm lesion (arrow) is demonstrated. Other signs of peritoneal tirnior spread include large amounts of ascites and focal thickening of the peritoneum in the right paracolic gutter...

Some ventral hernias are not seen at rest and are brought into view with only one of the manoeuvers. When the hernia is seen at rest, an attempt is made to slide the contents into the abdomen to know if the hernia is reducible. Sonography readily differentiates other conditions that mimic ventral hernia such as lipoma, metastasis, suture granuloma, abscess or endometriosis. Umbilical hernia is a type of ventral hernia that occurs through the weak umbilicus. Fatty epigastric hernia is protrusion of the properitoneal fat through a defect in the linea alba. 

Subsequently, through culture of the same fungus, Periconia byssoides, collected from the same mollusk, Aplysia kurodai, the same team isolated a series of irregular sesquiterpenes, peribysins A-D, which are inhibitors of cell adhesion of HL-60 (human leukemia) on HUVECs (human umbilical vein endothelial cells) and could be useful for the treatment of metastasis. Peribysin D is 380 times more active than herbimycin A, which is used as a standard (Yamada et al., 2004). 

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