Human Umbilical Cord Blood Stem Cells Transplants

2 Human Umbilical Cord Blood Stem Cells Transplants 

Although stem/progenitor cell and hUCB biotechnologists have realized commercial potentials of human stem cell research, clinical applications of human cell for the treatment of neurological disorders have been the subject of intense ethical and legislative considerations. Very little is known about neurochemical aspects 

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Broxmeyer, H.E., Gordon, G.W., Hangoc, G. et al. (1989) Human umbilical cord blood as a potential source of transplantable hematopoietic stem/ progenitor cells, Proc. Natl. Acad. ScL t/S 86 3828-3832. 

The problem is, the volume or number of CB cells is limited, as each umbilical cord has only enough cells to transplant into a small child. The thrust of the article, therefore, is the development of a method to proliferate or expand the number of CB cells by providing an appropriate medium. (The stem cells are designated CD34 cells, as they are available not only from CB but also from bone marrow and peripheral blood.) The animals involved in the testing were denoted as immunode-ficient NOS/SCID mice (where NOS/SCID pertains to nonobese diabetie/severe combined immimodeficient), and further denoted as the recipients of transplanted human CB cells, expanded (or proliferated) by the procedures described in the article. 

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