Regulation transcriptional

It has been considered that, in contrast with nNOS and iNOS, which are expressed in diverse tissues and cell types, ecNOS is relatively restricted to vascular endothelial cells. However, recent evidence suggests the existence of ecNOS in pyramidal neurons ofthe hippocampus (CAl region) (Dinerman et al., 1994 O Dell et al., 1994), syncytiotrophoblasts (Myatt et al., 1993), the LLC-PK] cell line derived from the kidneys (proximal tubule-like) (Tracey et al., 1994), NCI-H441 human bronchiolar epithelial cells (Shaul et al., 1994), and human platelets (Mehta et al., 1995). The molecular basis for the restricted cell-specific expression of this mRNA transcript remains to be determined. 

FIGURE 4 Potential trans-acting factor binding sites in the 5 -flanking region of the human endothelial constitutive nitric oxide synthase gene. Nucleotides are numbered relative to the major transcriptional start site ( + 1). See text for details. 

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Both catenanes and knots can bring together remote DNA sequences and may be important in transcription regulation and genetic recombination... 

Fuqua, W. C.,Winans, S. C.,and Greenberg, E. P. (1994). Quorum sensing in bacteria the LuxR-LuxI family of cell density-responsive transcriptional regulators./. Bacteriol. 176 269-275. 

The ankyrin repeat motif is one of the most common protein-protein interaction domains. Ankyrin repeats are modules of about 33 amino acids repeated in tandem. They are found in a large number of proteins with diverse cellular functions such as transcriptional regulators, signal transducers, cell-cycle regulators, and cytoskeletal proteins. 

PMURAR a Transcriptional regulator Inhibition of cell proliferation induction of apoptosis increase in sensitivity against ATRA... 

Androgen receptor Transcriptional regulator Inhibition of androgen receptor transcriptional activity... 

Hogan PG, Chen L, Nardone J et al (2003) Transcriptional regulation by calcium, calcineurin, and NFAT Genes Dev 17 2205-2232... 

Schmidt D, Muller S (2003) PIAS/SUMO new partners in transcriptional regulation. Cell Mol Life Sci 60 2561-2574... 

Sharrocks AD (2006) PIAS proteins and transcriptional regulation - more than just SUMO E3 ligases Genes Dev 20 754-758... 

Transcriptional regulation encompasses the modulation of the synthesis rate of mRNA due to cell type specific factors that may be triggered by external stimuli. 

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