Microarray analysis transcriptional regulation

In the next phase of the study, transcripts of up-regulated genes granulocyte colony-stimulating factor (G-CSF) and IgG were introduced into a mouse model corranonly used to test potential therapies for experimental autoimmune encephalomyelitis (EAE). Erom microarray analysis, G-CSF was found to be up-regulated in acute MS but not in the chronic state of the disease. Subcutaneous injection of G-CSF prior to induction of EAE prevented onset of the disease in mice. The reversal of EAE by G-CSE has also been described (see Eock, 2002, Reference 40). 

Zhou Y, Gwadry FG, Reinhold WC et al. Transcriptional regulation of mitotic genes by camptothecin-induced DNA damage microarray analysis of dose- and time-dependent elfects. Cancer Res 2002 62 1688-1695. 

Li Y, Lee KK, Walsh S, Smith C, Hadingham S, Sorefan K, Cawley G, Bevan MW. 2006b. Establishing glucose- and ABA-regulated transcription networks in Arabidopsis by microarray analysis and promoter classification using a Relevance Vector Machine. Genome Res 16 414-427. 

The dysregulation of transcription has provided a target for therapeutic intervention, and microarray analysis has been used to follow the effect of the drug in the treated samples. For example, acetylation of histones regulates... 

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