Regulation of gene transcription by growth factors and cytokines

Regulation of gene transcription by growth factors and cytokines 

This chapter focuses on control of gene transcription by growth factors and cytokines. This is part of our effort to find out how specific and unique cellular responses to growth promoters are accomplished. 

The c-jun gene is rapidly induced by a great variety of signals, ranging from growth factors and cytokines to lipid messengers and G proteins. 5 Each signal may result in a 

In Fig. 10.1 a scenario is shown, where different signals travelling over different signalling pathways eventually all converge on the promoter of the c-fos gene, but each signal addresses a different specific element in the gene promoter. This selective response 

Cytokine STAT/JAK pathway Receptor Tyrosine kinase RAS/MAPK pathway G-Protein coupled Receptor pathway  

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REGULATION OF GENE TRANSCRIPTION BY GROWTH FACTORS AND CYTOKINES 173... 

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