Development transcriptional regulators

Edgar BA, Lehman DA, O Farrell PH 1994 Transcriptional regulation of string(cdc25) a link between developmental programming and the cell cycle. Development 120 3131-3143... 

A mbros Less is known about how cki-1 is shut off in VPCs than about how cki-1 is turned on in these cells. However, when we misexpress lin-14 late in development, it will maintain cki-1 expression later than in the normal vulval lineage. Therefore, extinction of cki-1 expression in VPCs is influenced by some activity that is in turn dependent on lin-14 down-regulation. All our cki-1 expression constructs retain the 3hUTR of cki-1 (Hong et al 1998), and so the dynamic cki-1 expression we observe could reflect post-transcriptional regulation in addition to transcription regulation. 

Other approaches could use transcriptional regulators that directly bind the substrate or product of the reaction and activate the reporter gene. For instance, a mutant transcriptional activator from Pseudomonas putida, NahH, was used that can bind various benzoic acids to develop a screening/selection method to detect the action of benzaldehyde dehydrogenase [45]. A transcriptional regulator may need to be engineered to bind the desired compound before it can be used in such a manner [46]. 

Retinoic acid Regulation of vertebrate development transcription... 

Transcriptional regulator networks function in invertebrate development 445... 

Transcriptional regulator networks determine vertebrate development 447... 

He, X. and Rosenfeld, M. G. Mechanisms of complex transcriptional regulation implications for brain development. Neuron 7 183-196,1991. 

Glimcher LH, Townsend MJ, Sullivan BM, Lord GM Recent developments in the transcriptional regulation of cytolytic effector cells. Nat Rev Immunol 2004 4 900-911. 

These processes include cell proliferation, embryonic development, and sexual differentiation—i. e., processes that require a prolonged time period and involve proteins de novo synthesis. For this reason, mainly steroid hormones which function via transcription regulation are active in this field (see p. 244). 

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