Ligand-activated transcriptional regulator

The retinoic acids of retinoids could reveal widely their potential effects such as vertebrate development, cellular differentiation and vital homeostasis. A retinoic acid receptor RARal belonging to the superfamily of nuclear ligand-activated transcriptional regulators could regulate these receptors of steroid hormone, thyroid hormone, and vitamin D3. 

The mechanisms of corticosteroid receptor regulation of transcription have been elucidated. Both type I and type II corticosteroid receptors are members of a superfamily of ligand-activated transcription factors defined by protein sequence similarity. Included in this superfamily are various other steroid receptors, such as the estrogen receptor, as well as members of the retinoic acid receptor... 

The physiological effects of progesterone are mediated by two progesterone receptor isoforms termed PR-A and PR-E. These arise from a single gene and act as ligand-activated transcription factors to regulate the expression of... 

Kawada T, Kamei Y, and Sugimoto E (1996) The possibility of active form of vitamins A and Das suppressors on adipocyte development via ligand-dependent transcriptional regulators. International Journal of Obesity and Related Metabolic Disorders 20(Suppl 3),S52-7. 

Nuclear receptors (NR) function as ligand-activated transcription factors that regulate expression of a host of genes, including those coding for key drug-metabolizing enzymes and transporters. It is now known that the induction... 

Nuclear hormone receptors (NRs) are ligand-activated transcription factors that regulate gene expression by interacting with hormone response elements on target genes (see also Chapter 12). This occurs via the formation of monomers, homodimers, or heterodimers generally with the retinoid X receptor (RXR) and interaction with the hormone response element [83,84],... 

PPARy is a ligand-activated transcription factor which binds to sequence specific promoter elements of its target genes and directly regulates their... 

The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of the nuclear hormone receptor superfamily. The three PPAR isoforms (a, p/8, and y) are known to occur in mammalian tissues. In response to specific agonists, these receptors form dimers and translocate to the nucleus, where they act as agonist-dependent transcription factors and regulate gene... 

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