Transcriptional regulation posttranscriptional events

Between 10% and 20% of expressed genes in a cell are regulated by glucocorticoids. The number and affinity of receptors for the hormone, the complement of transcription factors and coregulators, and posttranscription events determine the relative specificity of these hormones actions in various cells. The effects of glucocorticoids are mainly due to proteins synthesized from mRNA transcribed... 

In conclusion, a number of events are related to non-antioxidant properties of a-tocopherol (Table 2), both at transcriptional and posttranscriptional level. However, whether a-tocopherol acts by a pleiotropic mechanism, or it binds to a receptor capable of regulating different reactions, still remains unknown. 

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