Genome transcriptional regulation

Fig. 5.1 Regulators of pre- and post-integration latency. Pre-integration latency is regulated as the viral RNA is reverse transcribed into the proviral DNA (A). This is controlled by the avaUabdity of the nucleotide pool, half life of the forming proviral cDNA copy, and the interaction of the viral protein Vif with the cellular antiviral protein APOBEC, espedaUy family members 3G and 3R It is also regulated at the step of transport across the nuclear membrane through the availability of ATP as the process requires energy (B). Post-integration, the proviral DNA copy of the viral genome, is regulated maiiily by the avadabdity of host transcription factors, especially NF-kB and NFAT (C)...

The higher-order architectures of DNA/protein complexes are achieved on the balance of the physical properties of DNA and the interactive forces of DNA-binding proteins (Hizume et al., 2002 Yoshimura et al, 2000). The superhelical strain of the DNA has been suggested to play a critical role in a variety of genome events such as transcriptional regulation and DNA replication (Opel et al, 2001). 

Jacob J, Sebastian KS, Devassy S, et al. Membrane estrogen receptors genomic actions and post transcriptional regulation. Mol Cell Endocrinol. 2006 ... 

Escherichia coli EcoCyc SRI International Comprehensive literature-based curation of the entire genome and of transcriptional regulation, transporters, and metabolic pathways for bacterium E. coli K-12 MG1655 (http //ecocyc.org/)... 

To study the transcriptional regulation of the DOR gene, mouse DOR genomic clones were isolated [15], Subsequent analysis revealed that the mouse... 

Harland, L., R. Crombie, S. Anson, J. deBoer, P.A. Ioannou, and M. Antoniou. 2002. Transcriptional regulation of the human TATA binding protein gene. Genomics 79 479-482. 

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