Negative transcriptional regulation

Riddick DS, Lee C, Bhathena A, Timsit YE. The 2001 Veylien Henderson Award of the Society of Toxicology of Canada. Positive and negative transcriptional regulation of cytochromes P450 by polycyclic aromatic hydrocarbons. Can J Physiol Pharmacol 2003 81 59-77. 

Stammers, D.K., Ren, J., Leslie, K. et al. 2001. The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehy-drogenase/reductases. Embo J 20 6619-6626. 

The arabinose operon features a single protein which acts as both a positive and a negative transcriptional regulator, depending upon the binding of particular ligands (Figure 26.39). 

Whether these MRTFs mediate separate activities with respect to positive and negative transcriptional regulation, and metal ion specificity and/or specificity for different MREs (and exactly how they mediate), remains unresolved. However, it is clear that there are multiple MRE-binding factors with metal-dependent (and, in the case of MRE-BP, metal-independent) DNA-binding activity. Since a single MRE is responsive to several different metal ions, it could be that ... 

Saatcioglu F, Claret FX, Karin M (1994) Negative transcriptional regulation by nuclear receptors. Semin Cancer Biol 5 347-359... 

XiE, Y. and Varshavsky, A. RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome a negative reedback circuit. Proc. Natl. Acad. Sci. (USA) 2001, 98, 3056-3061. 

In this system, cognate hormones act as positive regulating effectors. The transcription regulating activity of nuclear receptors can also be negatively influenced by specific inhibitor proteins. These proteins are characterized as repressors. 

Motohashi H, Katsuoka F, Shavit JA, Engel JD, Yamamoto M. 2000. Positive or negative MARE-dependent transcriptional regulation is determined by the abundance of small Maf proteins. Cell 103 865-875. 

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