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Eukaryotic transcription regulation

Most Eukaryotic Transcriptional Regulators Contain Discrete Functional Domains... [Pg.820]

Fig. 3.3-2 Prokaryotic regulators of transcription have been adapted for use as eukaryotic transcriptional regulators ... Fig. 3.3-2 Prokaryotic regulators of transcription have been adapted for use as eukaryotic transcriptional regulators ...
In eukaryotes, transcriptional regulation is mediated within the context of nucleosomes, the repeating subunits of chromatin. The core nucleo-some particle consists of 147 base pairs of DNA wrapped around the histone octamer composed of two copies of each of the four core histones H2A, H2B, H3, and H4. Each core histone is composed of a globular domain and an unstructured amino-terminal tail of 25-40 residues. This... [Pg.181]

Murdoch GH, Rosenfeld MG, Evans RM (1982) Eukaryotic transcriptional regulation and chromatin-associated protein phosphorylation by cyclic AMP. Science 218 1315-1317... [Pg.401]

C. Eukaryotic gene regulation is much more complex than in prokaryotes, with expression dependent on several types of transcription factors as well as chromatin structure. [Pg.178]

Cullen, B.R. and Mahm, M.H. Tire HIV-1 Rev-protein prototype of a novel class of eukaryotic post-transcriptional regulators (1991) Trends Biochem. Sd. 16, 346-350... [Pg.85]

We begin by examining the interactions between proteins and DNA that are the key to transcriptional regulation. We next discuss the specific proteins that influence the expression of specific genes, first in prokaryotic and then in eukaryotic cells. Information about posttranscriptional and translational regulation is included in the discussion, where relevant, to provide a more complete overview of the rich complexity of regulatory mechanisms. [Pg.1082]

Homeodomain Another type of DNA-binding domain has been identified in a number of proteins that function as transcriptional regulators, especially during eukaryotic... [Pg.1090]

Carey, M., and Smale, S. T. (2000) Transcriptional Regulation in Eukaryotes, Cold Spring Harbor Lab. Press, Cold Spring Harbor, New York... [Pg.1661]

Is transcription attenuation likely to be an important mechanism of transcriptional regulation in eukaryotic cells ... [Pg.1738]

McKinney, J. D., and N. Heintz, Transcriptional regulation in the eukaryotic cell cycle. Trends Biochem. Sci. 16 430-434, 1991. [Pg.828]

Roeder, R. G., The complexities of eukaryotic transcription initiation Regulation of preinitiation complex assembly. Trends Biochem. Sci. 16 402-407, 1991. [Pg.828]

Spencer, C.A. and Groudine, M. (1990) Transcription elongation and eukaryotic gene regulation. Oncogene, 5, 777-785. [Pg.28]

SELEX has also allowed the characterization of the RNA hairpin, which constitutes the iron responsive element (IRE) recognized by the iron regulatory factor (IRF) protein to post-transcriptionally regulate translatability and decay of mRNAs involved in iron import and storage in eukaryotic cells (Henderson et al., 1994). [Pg.88]

Transcription in eukaryotes an overview (G5) Transcription of protein-coding genes in eukaryotes (G6) Regulation of transcription by RNA Pol II (G7)... [Pg.167]

In eukaryotic organisms, transcription regulation is a complex process that demands coordinated interaction of several genetic elements. The efficiency of this process mainly depends on the promoter/enhancer sequences, the copy number of the gene, and the structure and elements present at the insertion site in the host s chromatin. On the other hand, the co-transcriptional modifications (capping, splicing, polyadenylation, and transport to cytoplasm) on the primary transcript determine the stability, turnover rate, and translational capacity of the future mRNA. [Pg.40]

Gallie, D.R., J.N. Feder, R.T. Schimke, and V. Walbot (1991). Post-transcriptional regulation in higher eukaryotes the role of the reporter gene in controlling expression. Mol. Gen. Genet. 228 258-264. [Pg.95]

Transcription and transcriptional regulation is more complicated in eukaryotes than in prokaryotes. The very much larger amount of DNA in eukaryotes is organized with histones... [Pg.340]

The fact that the two characterized eukaryotic Cu-regulated transcription factors are regulated by apparent formation of tetracopper clusters suggests that this may repeat as a structural motif in other systems. Both Acel and Mad contain a common structural motif, the small Zn module thus, it is also conceivable that this structural motif will be duplicated in other species. [Pg.86]

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See also in sourсe #XX -- [ Pg.466 ]



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