Gene Transcription regulation

Topical retinoids acting on gene transcription regulate cell proliferation and differentia-... 

L C. SCID-Xl (yC deficiency) is an optimal model for gene therapy because there is little yC gene transcription regulation yC expression is ubiquitous and constitutive among different hematopoietic Uncages and yC exerts no autonomous function. 

Histones are basic proteins that are made up by a globular domain and an N-terminal tail that protrudes from the nucleosome. Nucleosomes form the basic unit of chromatin and are made up by a complex of DNA wrapped around an octamer of histones formed by pairs of the histones H2A, H2B, H3, and H4 (45,46) (Fig. 1). Post-translational modification of the core histone tails by methylation, acetylation, phosphorylation, ubiquitina-tion, or sumoylation can alter the structure of the nucleosomes and thus alter gene expression. These post-translational modifications determine the structure and pattern of chromatin condensation and determine the histone code that drives gene transcriptional regulation (47,48). Below are briefly described the factors determining the histone acetylation and methylation. 

The induction of CYPlAl, the prototypical target gene transcriptionally regulated by the AHR, together with other CYPl enzymes accompanies toxicity in... 

Dinesh, A. and D. A. Nagegowda. 2010. Plant volatile terpenoid metabolism Biosynthetic genes, transcriptional regulation and subcellular compartmentation. 584 2965-2973. 

Mechanisms of Gene Transcriptional Regulation through Biotin and Biotin-Binding Proteins in Mammals... 

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