PIAS Proteins

Immune Defense JAK-STAT Pathway PIAS proteins Map Kinase Cascades Toll-like Receptors Growth Factors... 

STAT signaling occurs within minutes following activation but also underlies rapid deactivation by cytoplasmic phosphatases or antagonistic factors such as members of the SOCS-proteins themselves induced by activated STATs. Another group of proteins called PIAS (proteins that inhibit active STATs) inhibit binding of activated STATs to their target DNA sequences... 

With the exception of a variable carboxy-terminal region, the mammalian PIAS proteins all share a high degree of sequence homology and a common domain structure (Fig. 2). 

PIAS (protein inhibitors of activated STATs) proteins were first discovered in yeast-two-hybrid screens as interacting molecules with STAT transcription factors. The mammalian family consists ofthe founding member PIAS3, which was described as a repressor of STAT3, and three additional members, PIAS1, PIASy (also known as PIAS4), and PIASx (also known as... 

PIAS Proteins. Figure 1 Reporter gene assay with an interferon-y-driven artificial promoter demonstrating the inhibitory transcriptional activity of increasing amounts of PIAS on STAT1 signal transduction. 

Sharrocks AD (2006) PIAS proteins and transcriptional regulation - more than just SUMO E3 ligases Genes Dev 20 754-758... 

Shuai K, Liu B (2005) Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat Rev Immunol 5 593-605... 

Shuai K. 2006. Regulation of cytokine signaling pathways by PIAs proteins. Cell Res. 16 196-202. 

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